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Phospho-PKMYT1 (Ser83) Antibody

Datasheet
Code CSB-PA729561
Size US$360
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Image
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PKMYT1 Polyclonal antibody
Uniprot No.
Q99640
Target Names
PKMYT1
Alternative Names
cdc2 inhibitory kinase antibody; DKFZp547K1610 antibody; FLJ20093 antibody; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase antibody; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody; MYT1 antibody; Myt1 kinase antibody; PKMYT 1 antibody; Pkmyt1 antibody; PMYT1_HUMAN antibody; PPP1R126 antibody; Protein kinase membrane associated tyrosine/threonine 1 antibody; Protein kinase Myt1 antibody; Protein phosphatase 1 regulatory subunit 126 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of Serine 83(R-V-S(p)-F-R) derived from Human MYT1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PKMYT1 Antibodies

PKMYT1 Proteins

Customer Reviews and Q&A

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Target Background

Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Gene References into Functions
  1. Study found that PKMYT1 was essential for the proliferation and mobility of CRC cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease. PMID: 29658598
  2. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells PMID: 28648520
  3. Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis. PMID: 23241949
  4. MYT1 binds to TSAP6 in tumor cells and has a role in cell cycle regulation PMID: 12606722
  5. Myt1 is phosphorylated by polo-like kinase 1 PMID: 12738781
  6. overexpressed during the S phase of the cell cycle compared with the G0/1 phase PMID: 16476973
  7. The results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells. PMID: 18378775

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Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Database Links

HGNC: 29650

OMIM: 602474

KEGG: hsa:9088

STRING: 9606.ENSP00000262300

UniGene: Hs.732385

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Related pathways
Cell cycle
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