PLIN4 Antibody

Code CSB-PA822286HA01HU
Size US$299 How to order?
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  • Western Blot
    Positive WB detected in: A549 whole cell lysate
    All lanes: PLIN4 antibody at 2.7μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 135, 141 kDa
    Observed band size: 135 kDa

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA822286HA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA822286HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Description

CUSABIO produces the PLIN4 antibody by immunizing rabbits with the recombinant human PLIN4 protein (308-418AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is greater than 95% using protein G purified. It only shows reactivity with human PLIN4 protein, also known as S3-12, which is highly expressed in white adipose tissue and coats lipid droplets in adipocytes to protect them from lipases. This PLIN4 antibody can be applied in ELISA, WB, IHC, and IF analyses.

Full Product Name Rabbit anti-Homo sapiens (Human) PLIN4 Polyclonal antibody
Uniprot No. Q96Q06
Target Names PLIN4
Alternative Names Adipocyte protein S3 12 antibody; Adipocyte protein S3-12 antibody; hCG1646516 antibody; KIAA1881 antibody; Perilipin-4 antibody; Plasma membrane associated protein S3 12 antibody; Plin 4 antibody; PLIN4 antibody; PLIN4_HUMAN antibody; S3 12 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Perilipin-4 protein (308-418AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The PLIN4 Antibody (Product code: CSB-PA822286HA01HU) is Non-conjugated. For PLIN4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA822286HB01HU PLIN4 Antibody, HRP conjugated ELISA
FITC CSB-PA822286HC01HU PLIN4 Antibody, FITC conjugated
Biotin CSB-PA822286HD01HU PLIN4 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.
Gene References into Functions
  1. Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. PMID: 29626194
  2. Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
  3. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. PMID: 22667335
  4. we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits PMID: 22210160
  5. These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site PMID: 21533135
  6. Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
  7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20495294
  8. Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. PMID: 12840023

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Subcellular Location Cell membrane. Cytoplasm. Lipid droplet.
Protein Families Perilipin family
Database Links

HGNC: 29393

OMIM: 613247

KEGG: hsa:729359

STRING: 9606.ENSP00000301286

UniGene: Hs.591387

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