PLIN4 Antibody

1. Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. PMID: 29626194
2. Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
3. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. PMID: 22667335
4. we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits PMID: 22210160
5. These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site PMID: 21533135
6. Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20495294
8. Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. PMID: 12840023

Show More

Hide All

HGNC: 29393

OMIM: 613247

KEGG: hsa:729359

STRING: 9606.ENSP00000301286

UniGene: Hs.591387