Recombinant Human Perilipin-4(PLIN4) ,partial

Code CSB-MP822286HU
Size US$1400 How to order?
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names PLIN4
Uniprot No. Q96Q06
Research Area Cardiovascular
Alternative Names Adipocyte protein S3 12 ; Adipocyte protein S3-12; hCG1646516; KIAA1881; Perilipin-4; Plasma membrane associated protein S3 12 ; Plin 4; PLIN4; PLIN4_HUMAN; S3 12
Species Homo sapiens (Human)
Source Mammalian cell
Expression Region 308-418aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 14.9kDa
Protein Length Partial
Tag Info N-terminal 6xHis-Myc-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer Tris-based buffer,50% glycerol
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets.
Gene References into Functions
  1. Using synthetic lipids, we show that Plin4 amphipathic helix (AH) binds poorly to lipid bilayers but strongly interacts with pure triglycerides, acting as a coat and forming small oil droplets. Because Plin4 overexpression alleviates lipid droplet (LD) instability under conditions where their coverage by phospholipids is limiting, we propose that the Plin4 AH replaces the LD lipid monolayer, for example during LD growth. PMID: 29626194
  2. Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms. PMID: 29361938
  3. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. PMID: 22667335
  4. we found a significant association between one single-nucleotide polymorphism in PLIN4 and height but not with bone traits PMID: 22210160
  5. These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site PMID: 21533135
  6. Those findings indicate improvement and conservation of lifestyle depending on genetic predisposition in ADIPOQ, PLIN and LIPE should be encouraged. PMID: 20495294
  7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20495294
  8. Characterization of homologous mouse gene product, plasma membrane associated protein, S3-12. PMID: 12840023

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Subcellular Location Cell membrane. Cytoplasm. Lipid droplet.
Protein Families Perilipin family
Database Links

HGNC: 29393

OMIM: 613247

KEGG: hsa:729359

STRING: 9606.ENSP00000301286

UniGene: Hs.591387

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