PMEPA1 Antibody

Code CSB-PA628756
Size US$100
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  • Western blot analysis of 823 22RV1 HELA HEPG2 Cell Lysate, antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
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Product Details

Uniprot No.
Target Names
PMEPA1
Alternative Names
PMEPA_HUMAN antibody; PMEPA1 antibody; Prostate transmembrane protein; androgen induced 1 antibody; Solid tumor associated 1 protein antibody; Solid tumor-associated 1 protein antibody; STAG1 antibody; TMEPAI antibody; Transmembrane prostate androgen induced protein antibody; Transmembrane prostate androgen-induced protein antibody; Transmembrane; prostate androgen induced RNA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide from Human protein at AA range: 1268-1341
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
WB,ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000-1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Gene References into Functions
  1. JHY-A007-50 mediates the downregulation of TMEPAI expression. PMID: 30069967
  2. describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases PMID: 29945215
  3. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
  4. study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1. PMID: 27163528
  5. these findings indicated that PMEPA1 participates in TGF-beta- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression. PMID: 27697531
  6. the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression. PMID: 27035427
  7. Sp1 up-regulated TMEPAI protein expression, as well as Sp1 promoting TMEPAI-induced cell proliferation. PMID: 27625141
  8. PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. PMID: 26758191
  9. these data elaborated on the diverse activity among TCF/LEF family members with respect to the transcriptional regulation of the TMEPAI gene. PMID: 26590303
  10. Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells. PMID: 26927372
  11. Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein. PMID: 25883222
  12. Downregulation of PMEPA1 may result in increased androgen receptor protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis. PMID: 24694733
  13. EGF signaling collaboratively regulates TGF-beta-induced TMEPAI expression. PMID: 25482449
  14. TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 is required for the transport of TMEPAI to the lysosome. PMID: 24933703
  15. TMEPAI promotes tumorigenic activities in lung cancer cells. PMID: 24438557
  16. The levels of TMEPAI in lung tumor tissues are very high. PMID: 23615405
  17. Differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. PMID: 17318295
  18. Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta from a tumor suppressor to a tumor promoter. PMID: 20610632
  19. Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases. PMID: 12670906
  20. PMEPA1 negatively regulates growth of androgen responsive or refractory prostate cancer cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein. PMID: 12907594
  21. DNA methylation within the PMEPA1 promoter downstream sequences suggests that methylation of SP1 binding sites may also contribute to the repression of PMEPA1 gene PMID: 18174752
  22. decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of the NEDD4-binding protein PMEPA1 in prostate cancers PMID: 18703514

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Subcellular Location
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Protein Families
PMEPA1 family
Tissue Specificity
Highest expression in prostate. Also expressed in ovary.
Database Links

HGNC: 14107

OMIM: 606564

KEGG: hsa:56937

STRING: 9606.ENSP00000345826

UniGene: Hs.517155

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