POLDIP3 Antibody

1. Altered expression of PDIP46 or its mutation may affect Pol delta functions in vivo, and thereby be a nexus for altered genomic stability. PMID: 26819372
2. hnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA. PMID: 25378556
3. PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PMID: 22928037
4. these findings establish critical and essential roles for SKAR in the regulation of mRNA translation of IFN-sensitive genes and induction of IFN-alpha biological responses. PMID: 25049393
5. Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with amyotrophic lateral sclerosis (ALS) . PMID: 22900096
6. SKAR is a specific target of S6K1 and regulates cell growth. PMID: 15341740
7. This study showed that PDIP46 aka SKAR, a protein possessing one RNA recognition motif (RRM) and being a protein partner of both the p50 subunit of DNA polymerase delta and p70 ribosomal protein S6 kinase 1 (S6K1). PMID: 16984396
8. SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis. PMID: 18423201

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HGNC: 23782

OMIM: 611520

KEGG: hsa:84271

STRING: 9606.ENSP00000252115

UniGene: Hs.505802