PPP2R1B Antibody

1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176

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HGNC: 9303

OMIM: 603113

KEGG: hsa:5519

STRING: 9606.ENSP00000311344

UniGene: Hs.269128