PPP2R1B Antibody

Code CSB-PA830420ESR2HU
Size US$299 How to order?
Image
  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA830420ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA830420ESR2HU at dilution of 1:100

  • IHC image of CSB-PA830420ESR2HU diluted at 1:403 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PPP2R1B Polyclonal antibody
Uniprot No. P30154
Target Names PPP2R1B
Alternative Names 2AAB_HUMAN antibody; beta isoform of regulatory subunit A; protein phosphatase 2 antibody; PP2A A beta antibody; PP2A subunit A isoform PR65-beta antibody; PP2A subunit A isoform R1-beta antibody; PP2A; subunit A; PR65 beta isoform antibody; PP2A; subunit A; R1 beta isoform antibody; PPP2R1B antibody; PPP4R1 antibody; PR65B antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform antibody; Protein phosphatase 2; regulatory subunit A; beta antibody; Protein phosphatase 2; structural/regulatory subunit A; beta antibody; protein phosphatase 2; structural/regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform protein (402-601AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Gene References into Functions
  1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
  2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
  3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
  4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
  5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
  6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
  7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
  8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
  9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
  10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
  11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176

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Protein Families Phosphatase 2A regulatory subunit A family
Database Links

HGNC: 9303

OMIM: 603113

KEGG: hsa:5519

STRING: 9606.ENSP00000311344

UniGene: Hs.269128

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