Product Details

Uniprot No.

Target Names

PPP2R1B

Alternative Names

2AAB_HUMAN antibody; beta isoform of regulatory subunit A; protein phosphatase 2 antibody; PP2A A beta antibody; PP2A subunit A isoform PR65-beta antibody; PP2A subunit A isoform R1-beta antibody; PP2A; subunit A; PR65 beta isoform antibody; PP2A; subunit A; R1 beta isoform antibody; PPP2R1B antibody; PPP4R1 antibody; PR65B antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform antibody; Protein phosphatase 2; regulatory subunit A; beta antibody; Protein phosphatase 2; structural/regulatory subunit A; beta antibody; protein phosphatase 2; structural/regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human PP2A-Aβ.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IHC	1:200-1:1000
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Gene References into Functions	MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730 For PPP2R1B, no mutations were detected in our samples. PMID: 23588898 Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167 Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745 apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831 PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517 Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019 These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501 PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570 PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237 These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176 Show More Hide All
Protein Families	Phosphatase 2A regulatory subunit A family
Database Links	HGNC: 9303 OMIM: 603113 KEGG: hsa:5519 STRING: 9606.ENSP00000311344 UniGene: Hs.269128

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Check Code：

Code	CSB-PA003833
Size	US$167 How to order?
Image	Western Blot analysis of Jurkat cells using PP2A-Aβ Polyclonal Antibody
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PPP2R1B Antibody

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