PPP2R1B Antibody

Code CSB-PA003833
Size US$100
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  • Western Blot analysis of Jurkat cells using PP2A-Aβ Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
PPP2R1B
Alternative Names
2AAB_HUMAN antibody; beta isoform of regulatory subunit A; protein phosphatase 2 antibody; PP2A A beta antibody; PP2A subunit A isoform PR65-beta antibody; PP2A subunit A isoform R1-beta antibody; PP2A; subunit A; PR65 beta isoform antibody; PP2A; subunit A; R1 beta isoform antibody; PPP2R1B antibody; PPP4R1 antibody; PR65B antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); beta isoform antibody; protein phosphatase 2 (formerly 2A); regulatory subunit A; beta isoform antibody; Protein phosphatase 2; regulatory subunit A; beta antibody; Protein phosphatase 2; structural/regulatory subunit A; beta antibody; protein phosphatase 2; structural/regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A; beta isoform antibody; serine/threonine protein phosphatase 2A; 65 kDa regulatory subunit A; beta isoform antibody; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human PP2A-Aβ.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IHC 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Gene References into Functions
  1. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. PMID: 26247730
  2. For PPP2R1B, no mutations were detected in our samples. PMID: 23588898
  3. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B. PMID: 21420167
  4. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues. PMID: 20133745
  5. apoptosis mediated by Fas, TNF-alpha, and TRAIL in U937 cells is suppressed by calyculin A, an inhibitor of type-1 and type-2A protein phosphatases PMID: 14576831
  6. PPP2R1B has a role in regulating activity of specific downstream target proteins for cell cycle regulation in colorectal cancers PMID: 14767517
  7. Functional interaction between PR65, a regulatory subunit of the protein phosphatase 2A (PP2A), and CFTR was shown. PMID: 15936019
  8. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC. PMID: 17324501
  9. PPP2R1B genes may not play a role in the carcinogenesis of cervical cancer. Mutations of PPP2R1B gene are not frequent in cervical cancer. PMID: 17343570
  10. PPP2R1B, together with NPAT and CUL5, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
  11. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA. PMID: 17540176

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Protein Families
Phosphatase 2A regulatory subunit A family
Database Links

HGNC: 9303

OMIM: 603113

KEGG: hsa:5519

STRING: 9606.ENSP00000311344

UniGene: Hs.269128

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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