PPP2R2D Antibody, FITC conjugated

Code CSB-PA727750LC01HU
Size US$299 How to order?
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PPP2R2D Polyclonal antibody
Uniprot No. Q66LE6
Target Names PPP2R2D
Alternative Names 2ABD_HUMAN antibody; MDS026 antibody; PP2A subunit B isoform B55-delta antibody; PP2A subunit B isoform delta antibody; PP2A subunit B isoform PR55-delta antibody; PP2A subunit B isoform R2-delta antibody; PPP2R2D antibody; Protein phosphatase 2 regulatory subunit B delta antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform protein (1-192AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene References into Functions
  1. Results show that PPP2R2D expression was significantly upregulated at the mRNA and protein levels in gastric cancer (GC) tissues and correlated with poor prognosis. Further evidence demonstrates an oncogenic role of PPP2R2D in GC progression and development through regulation of mTOR. PMID: 29568966
  2. The PP2A regulatory subunit PPP2R2D inhibits T-cell proliferation and survival within tumors. PMID: 24596207
  3. The -462 G>A variant of PPP2R2D affects NF1 binding to the proximal promoter of PPP2R2D. PMID: 22539979
  4. These highly related members of the same subfamily of PP2A regulatory subunits differentially regulate TGF-beta/Activin/Nodal signalling to elicit opposing biological outcomes. PMID: 18697906
Subcellular Location Cytoplasm.
Protein Families Phosphatase 2A regulatory subunit B family
Database Links

HGNC: 23732

OMIM: 613992

KEGG: hsa:55844

STRING: 9606.ENSP00000399970

UniGene: Hs.380372

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