PRDX1 Antibody

Code CSB-PA018653ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot
    All lanes: Peroxiredoxin-1 antibody at 2μg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 22 kDa
    Observed band size: 22 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018653ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PRDX1 Polyclonal antibody
Uniprot No. Q06830
Target Names PRDX1
Alternative Names Heme binding 23 kDa protein antibody; MSP23 antibody; Natural killer cell-enhancing factor A antibody; NKEF A antibody; NKEF-A antibody; NKEFA antibody; OSF3 antibody; Osteoblast specific factor 3 antibody; PAG antibody; Paga antibody; PAGB antibody; Peroxiredoxin 1 antibody; Peroxiredoxin-1 antibody; PRDX1 antibody; PRDX1_HUMAN antibody; Proliferation associated gene A antibody; Proliferation-associated gene protein antibody; PRX1 antibody; PrxI antibody; TDPX2 antibody; Thioredoxin peroxidase 2 antibody; Thioredoxin-dependent peroxide reductase 2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Peroxiredoxin-1 protein (1-199AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
Gene References into Functions
  1. Even low doses of radiation employed for dental purposes are capable to provoke stress to cells, which was demonstrated via the induction of the antioxidant gene PRDX1. In elderly patients, such mechanism was demonstrated to be impaired. PMID: 29063384
  2. PRDX1 expression is low in osteosarcoma and fibrosarcoma tumors. PRDX1 suppressed the progression and metastasis of osteosarcoma and fibrosarcoma cells. PMID: 29908016
  3. that Peroxiredoxin1 expression predicted poor prognosis by regulating the tumor metastasis and angiogenesis of colorectal cancer PMID: 29673884
  4. The mRNA and protein levels of Prdx1 in the GC tissues were higher than in the peri-tumor tissues. Authors also found that high Prdx1 expression was positively correlated with the lymph node invasion and poor prognosis. PMID: 29656298
  5. these data ascertain the existence of an H2O2-sensitive PRDX1-FOXO3 signaling axis that fine tunes FOXO3 activity toward the transcription of gene targets in response to oxidative stress. PMID: 28398822
  6. Study uncovered a novel interaction between APE1 and PRDX1, which existed in both the nuclear and cytosolic fractions. Its knockdown enhances APE1 detection in the nucleus and stimulates IL-8 expression. Also, in gastric cancer patients, PRDX1 mRNA expression level is reduced and correlates with poor survival. PMID: 27388124
  7. Median PRDX1 levels were significantly higher in stroke patients compared to controls. PMID: 27924073
  8. The epimutation is present in three generations and results from PRDX1 mutations that force antisense transcription of MMACHC. PMID: 29302025
  9. Peroxiredoxin I (Prx I) increased in tumors of hepatocellular carcinoma (HCC) patients that aligned with overexpression of oncogenic H-ras. PMID: 27517622
  10. Prx1 might play an oncogenic role in tobacco-related oral squamous cell carcinoma and thus serve as a target for chemopreventive and therapeutic interventions. PMID: 27259998
  11. PRDX1 safeguards telomeres from oxygen radicals to counteract telomere damage and preserve telomeric DNA for elongation by telomerase. PMID: 28009281
  12. infection results in S-nitrosylation of multiple host proteins, including Prx1. PMID: 27612662
  13. circulating Prdx1 provides not only prognostic information but may be a promising target against ischemia/reperfusion injury. PMID: 27142532
  14. our findings suggest that the tumor suppressor activity of SIRT2 requires its ability to restrict the antioxidant activity of Prdx-1, thereby sensitizing breast cancer cells to reactive oxygen species -induced DNA damage and cell cytotoxicity PMID: 27503926
  15. UV-vis spectra of heme-PRX1 suggested that Cys52 is the axial ligand of ferric heme. PRX1 peroxidase activity was lost upon heme binding, reflecting the fact that Cys52 is not only the heme-binding site but also the active center of peroxidase activity. PMID: 28082197
  16. Prx1 and Prx2 are likely targets of urate hydroperoxide in cells. Oxidation of Prxs by urate hydroperoxide might affect cell function and be partially responsible for the pro-oxidant and pro-inflammatory effects of uric acid. PMID: 28348082
  17. Data suggest that PRX1 is a dual-function enzyme exhibiting both thioredoxin peroxidase-like activity and catalase-like activity with varied affinities towards reactive oxygen species; studies were conducted using recombinant proteins from green spotted puffer fish Tetraodon nigroviridis and from human. PMID: 28219939
  18. peroxiredoxin 1 has a role in redox sensing and transducing [review] PMID: 27756681
  19. Activation of PRX1 and -2 indicate cold atmospheric plasma affects redox homeostasis in osteosarcoma cells PMID: 28314261
  20. Data show that peroxiredoxins PRDX1 and PRDX2 are upregulated in tumor B cells as compared with normal counterparts. PMID: 26636537
  21. Data show the protein partners of human Prx1 and Prx2 and identified three sequence motifs, or combination thereof in Prxs partners, namely: CXXC, PXXP, and LXXLL. that can be important for protein localization, function and biological pathways. [review] PMID: 26548861
  22. The data indicate that Prdx1 may contribute to the development and progression of hilar cholangiocarcinoma PMID: 26617696
  23. Our data suggest that PRX1 inactivation could represent an interesting strategy to enhance cancer cell sensitivity to vitK3, providing a potential new therapeutic perspective for this old molecule. PMID: 26689287
  24. TRX-1/PRX-1 levels are associated with NADPH oxidase-activity in vivo and in vitro in atherosclerosis. PMID: 26117319
  25. PRDX1 was overexpressed in the tumor tissues of liver cancer and served as an independent poor prognostic factor for overall survival. PRDX1 can be modified by small ubiquitin-like modifier to play specific roles in hepatocarcinogenesis. PMID: 26478675
  26. The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 gene in 80 and 68 % of the tested clinical cases, respectively. PMID: 26159854
  27. the protein and mRNA levels of PRDX1 were significantly elevated under insulin-resistant conditions PMID: 26301632
  28. Prdx1 associates with the formation of membrane protrusions through modulation of the activity of p38 MAPK, which in turn promotes pancreatic ductal adenocarcinoma cell invasion. PMID: 25426613
  29. These findings that Prdx1 may be involved in tumorigenesis in esophageal squamous cell carcinoma PMID: 25579166
  30. Dephosphorylation of PrxI by okadaic acid-sensitive phosphatases during late mitosis again shields the centrosome from H2O2 and thereby allows the reactivation of Cdk1-opposing phosphatases at the organelle. PMID: 26150388
  31. This review will summarize the molecular basis of differences in the affinity of Srx for individual Prx and the role of individual component of the Srx-Prx system in tumor progression and metastasis. PMID: 26170166
  32. Overexpression of PRDX1 resulted in a higher resistance of cells to BCNU treatment PMID: 25484280
  33. PRDX1 is shown to be an independent predictor of improved outcomes in ER-positive breast cancer. PMID: 25011585
  34. The K(27)-acetylated hPrx1 exhibited greatly enhanced chaperone activity (e.g. protecting the protein malate dehydrogenase (MDH) from thermally induced aggregation and assisting the refolding of denatured citrate synthase). PMID: 25082442
  35. High level of PRDX1 expression is associated with lymph node metastasis and lung tumor differentiation. PMID: 23914992
  36. MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer. PMID: 23971998
  37. because of the lower amount of total PRDX1 and PRDX6 and the high thiol oxidation of these PRDXs, very little (less than 20%) protection due to PRDXs remains in infertile men, and this is associated with impaired sperm function and poor DNA integrity PMID: 22492841
  38. Hypoexpression of PRDX1 is associated with papillary thyroid carcinomas. PMID: 24316730
  39. increased Prdx1 expression is associated with tumor angiogenesis and progression in hepatocellular carcinoma PMID: 24297309
  40. results suggest that NGF-trkA signaling is involved in mechanical allodynia in paclitaxel-induced neuropathy PMID: 24480440
  41. The data indicate that Prdx1 may contribute to malignant transformation of the esophagus, and may be used as a biomarker in the immunodiagnosis of ESCC. PMID: 24009050
  42. cellular distribution of Peroxiredoxin I and II in human eyes PMID: 24152995
  43. Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by the glutaredoxin system. PMID: 24062305
  44. Our findings suggest that Prx1 may modulate the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis. PMID: 23615915
  45. Prdx1 orchestrates redox signaling in an H2O2 dose-dependent manner through the oxidation status of its peroxidatic cysteine Cys52. PMID: 23334324
  46. Data indicate that AMP-dependent kinases (AMPKalpha1 and AMPKalpha2) inhibit caveolin-1 phosphorylation by stabilizing the interaction between c-Abl and Prdx-1. PMID: 23723070
  47. study identified Pin1 as a novel PRDX1 binding protein and proposed a mechanism for Pin1 in regulating the metabolism of reactive oxygen species in cells PMID: 23421996
  48. expression of Prxs I and IV, both at mRNA and protein levels, was associated with light chain secretion quantified by ELISA. PMID: 23737084
  49. observations suggest that PRDX1 acts as a pro-cancer protein in HCC HepG2 cells. PMID: 23277276
  50. The protein and mRNA expressions of Prx1 and Prx6 increased significantly in the order of normal brain tissue, grade II astrocytoma, grade III astrocytoma and grade IV astrocytoma. PMID: 22985558
  51. The results obtained indicated a protective role for PrxI in counteracting amyloid beta peptide injury by increasing cell viability, preserving neurites, and decreasing cell death. PMID: 23060010
  52. NO/SNO donors such as S-nitrosocysteine and S-nitrosoglutathione readily induced the S-nitrosylation of Prx1, causing structural and functional alterations PMID: 23479738
  53. Mst1 inactivates Prdx1 by phosphorylating it at Thr-90 and Thr-183, leading to accumulation of hydrogen peroxide in cells. PMID: 23386615
  54. Drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the importance of redox-dependent mechanisms into development of cisplatin resistance. PMID: 23113308
  55. study suggested that positive ILK and PRDX1 expressions are closely related to the progression and poor prognosis of gallbladder cancer PMID: 23065574
  56. Two cytosolic peroxiredoxins (Prdx1 and Prdx2) have distinct roles in the cellular peroxide signaling and compete for available peroxide substrate. PMID: 22902630
  57. PRDX-1 mRNA and PRDX-1 protein were both more abundant in CD68(+)MR(-) than CD68(+)MR(+) macrophages in abdominal aortic aneurysms. PMID: 23241402
  58. These findings suggest that hPrx1 may perform biological functions as a RNA-binding protein, which are distinctive from known functions of hPrx1 as a reactive oxygen species scavenger. PMID: 22877757
  59. altered expression of peroxiredoxin 1 and radixin-moesin-binding phosphoprotein 50 may be used as prognostic markers in cholangiocarcinoma. PMID: 22446018
  60. Plasma peroxiredoxins 1 and 2, and tropomyosin 4 were shown to associate with asbestos-exposure, and peroxiredoxin 1 with lung cancer. PMID: 22537621
  61. epigenetic silencing of PRDX1 is frequent in 1p/19q-deleted oligodendroglial tumours and likely contributes to radio- and chemosensitivity of these tumours PMID: 22158042
  62. These findings provide new insight into the role of hPrx1 in regulating TGF-beta1-induced epithelial-mesenchymal transition . PMID: 22475482
  63. Data suggest that SNPs of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. PMID: 22215146
  64. Finding of elevated levels of PRDX1 in the serum of EOC patients versus normal/benign patients warrants further evaluation as a tumor specific biomarker for epithelial ovarian cancer. PMID: 21980378
  65. expression and function of Prdx1 and Prdx6 in MCF-7 and noncancerous MCF-10A cell lines; found elevated Prdx1 expression in MCF-7 cells and comparable expression of Prdx6; data suggest synergistic role for Prdx1 and Prdx6 in MCF-10A cells PMID: 22236188
  66. results show a novel PRX-I function to cause cell death in response to high levels of oxidative stress by activating MST1, which underlies the p53-dependent cytotoxicity caused by anticancer agents PMID: 21516123
  67. glutathionylation of Prx I promotes changes in its quaternary structure from decamers to smaller oligomers and concomitantly inactivates its molecular chaperone function PMID: 21401077
  68. The high expressions of Prx1, Trx1 and HIF-1alpha were related to invasion and lymph node metastasis in papillary thyroid carcinoma. PMID: 19558833
  69. PRX-1 serum levels are increased in abdominal aortic aneurysm (AAA) patients and correlate with AAA size and growth rate, suggesting the potential use of PRX-1 as a biomarker for AAA evolution. PMID: 21273562
  70. these results implicate Prx1 as a tumor-derived inducer of inflammation PMID: 21343392
  71. Prdx1 is the host factors required for efficient transcription and replication of measles virus. PMID: 21159870
  72. PRDX1 was associated with the cyclooxygenase (COX)-2 upstream promoter region at sites occupied by NF-kappaB in ER- but not in ER+ breast cancer cells. PMID: 20631257
  73. E6AP mediates the ubiquitin-dependent proteasomal degradation of Prx1 PMID: 20589759
  74. Phosphorylation of Prx1 (Ser-32) by TOPK prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of Prx1 peroxidase activity and blockade of intracellular H(2)O(2) accumulation. PMID: 20647304
  75. These results suggest that Prdx-1 and Prdx-4 are essential for preventing respiratory syncytial virus-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells. PMID: 20610706
  76. Prdx 1 was found to be the strongest overexpressed protein in malignant ovarian tumors among the selected proteins. Prdx 1 expression (>50% positive cancer cells) was significantly correlated with poor overall survival in ovarian serous carcinomas. PMID: 19902980
  77. Studies present the 2.1 A crystal structure of human Srx in complex with PrxI, ATP, and Mg(2+). PMID: 19812042
  78. Results show Prx1 increases the affinity of androgen receptor to dihydrotestosterone (DHT) and decreases the rate of DHT dissociation from the occupied receptor. PMID: 19737972
  79. Protein levels of Prx-I and Prx-II were significantly increased in Alzheimer Disease and Down Syndrome. PMID: 11771746
  80. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site PMID: 11904290
  81. regulation of activity by Cdc2-mediated phosphorylation PMID: 11986303
  82. 2-Cys Prxs act in a mutually nonredundant and sometimes stress-specific fashion to protect human cells from oxidant injury. The substantial resistance of human cells to hydroperoxides may result in part from the additive action of multiple Prxs PMID: 12080185
  83. Data show that peroxiredoxin I (Prx I)activity decreased gradually during catalysis, coincident with the conversion of Prx I to a more acidic species. PMID: 12161445
  84. No detectable changes in expression of peroxiredoxin 1 are observed in postmortem cerebellum or frontal cortex of patients with Down syndrome, Alzheimer or Pick's disease. PMID: 12650976
  85. results show that the sulfinic form of peroxiredoxin I, produced during the exposure of cells to H2O2, is rapidly reduced to the catalytically active thiol form PMID: 12714748
  86. Prx I and Trx expression is increased in lung cancer cells following hypoxia and in human lung cancer tissues PMID: 14703116
  87. results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503
  88. mammalian sulfiredoxin reactivates hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine PMID: 15448164
  89. Prx I and Prx II are induced at the early and late stage of differentiation of normal human epidermal keratinocytes. PMID: 15864612
  90. expression in squamous cell carcinoma of the tongue indicates tumors with a high potential for recurrence PMID: 15955662
  91. Prdx1 is activated by histone deacetylase inhibitor FK228, which causes apoptosis induction in esophageal cancer cells PMID: 16278420
  92. Our findings collectively suggest that non-classical secretion of Prx-I is induced by TGF-beta1, which is constitutively activated by furin in A549 cells. PMID: 16677601
  93. Aspartate-187 of peroxiredoxin (Prx) I is the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by human sulfiredoxin. PMID: 17176052
  94. Human Prdx1 and Prdx2 possess unique functions and regulatory mechanisms and that Cys(83) bestows a distinctive identity to Prdx1. PMID: 17519234
  95. Cytoplasmic perocyredoxin 1 inhibited NF-kappaB activation and nuclear translocation. PMID: 17603937
  96. In the normal human ciliary body, PRDX I, II and III were immunolocalized to the non-pigmented epithelial cells and ciliary muscle fibers. It suggests that 2-Cys PRDXs may have physiological functions to protect cells in human ciliary body. PMID: 17707450
  97. hippocampal neurons transfected with wild type Prx1 exhibit increased Abeta resistance PMID: 17761673
  98. Loss of PRDX1 is associated with esophageal squamous cell carcinoma PMID: 17786348
  99. Cell survival-enhancing property of Prx1 has been attributed to its antioxidant activity, the reactive oxygen species-scavenging activity of Prx1 was not essential for AR stimulation; Prx1 itself was oxidized and inactivated by hypoxia/reoxygenation. PMID: 17909037
  100. 2.6 A crystal structure of the human Srx-PrxI complex PMID: 18172504

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Subcellular Location Cytoplasm, Melanosome
Protein Families Peroxiredoxin family, AhpC/Prx1 subfamily
Database Links

HGNC: 9352

OMIM: 176763

KEGG: hsa:5052

STRING: 9606.ENSP00000262746

UniGene: Hs.180909

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