PRSS2 Antibody

Datasheet

Code	CSB-PA018814LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: BxPC-3 whole cell lysate(30µg), Raji whole cell lysate(30µg), HT-29 whole cell lysate(30µg), U937 whole cell lysate(30µg), PC-12 whole cell lysate(30µg), 293 whole cell lysate(30µg),293T whole cell lysate(30µg) All lanes: PRSS2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/40000 dilution Predicted band size: 27 kDa Observed band size: 27 kDa Exposure time: 120s IHC image of CSB-PA018814LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRSS2 Polyclonal antibody

Uniprot No.

P07478

Target Names

PRSS2

Alternative Names

Anionic trypsinogen antibody; EC 3.4.21.4 antibody; MGC111183 antibody; MGC120174 antibody; Protease serine 2 preproprotein antibody; Protease; serine; 2 (trypsin 2) antibody; Protease; serine; 2 antibody; Protease; serine; 2; preproprotein antibody; Prss2 antibody; Serine protease 2 antibody; TRY2 antibody; TRY2_HUMAN antibody; TRY8 antibody; TRYP2 antibody; Trypsin 2 antibody; Trypsin II antibody; Trypsin-2 antibody; Trypsinogen 2 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthesized peptide derived from human RSS2 protein

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO's product CSB-PA018814LA01HU is a PRSS2 polyclonal antibody raised in the rabbit against the recombinant human PRSS2 protein (24-247AA). It exists as the unconjugated IgG isoform. It is purified by protein G and reaches up to 95% in purity. And it shows reactivity with human and mouse samples. This PRSS2 antibody can recognize PRSS2 protein in ELISA, WB, and IHC applications. The PRSS2 protein is found at high levels in pancreatic juice and is upregulated in human pancreatitis and chronic alcoholism.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

In the ileum, may be involved in defensin processing, including DEFA5.

Gene References into Functions

evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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Subcellular Location

Secreted, extracellular space.

Protein Families

Peptidase S1 family

Tissue Specificity

Expressed in Paneth cells, at the base of small intestinal crypts.

Database Links

HGNC: 9483

OMIM: 601564

KEGG: hsa:5645

UniGene: Hs.449281

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Service

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Protein Service

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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