PSMD2 Antibody

Datasheet

Code	CSB-PA995612
Size	US$297
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Image	Western blot analysis of extracts from HT-29 cells, HeLa cells and 293 cells, using PSMD2 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMD2 Polyclonal antibody

Uniprot No.

Q13200

Target Names

PSMD2

Alternative Names

26S proteasome non-ATPase regulatory subunit 2 antibody; 26S proteasome regulatory subunit RPN1 antibody; 26S proteasome regulatory subunit S2 antibody; 26S proteasome subunit p97 antibody; 55.11 protein antibody; MGC14274 antibody; P97 antibody; Proteasome (prosome macropain) 26S subunit non ATPase 2 antibody; Proteasome 26S subunit; non-ATPase; 2 antibody; Proteasome 26S; subunit 2 antibody; Protein 55.11 antibody; Psmd2 antibody; PSMD2_HUMAN antibody; Rpn1 antibody; S2 antibody; TNFR associated protein 2 antibody; TRAP2 antibody; Tumor necrosis factor receptor associated protein 2 antibody; Tumor necrosis factor type 1 receptor-associated protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from N-terminal of Human PSMD2.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.; Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.

Gene References into Functions

the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1 PMID: 23667555
Results suggest that PSMD2 may be a good molecular target candidate. PMID: 21465578
These data suggest that p97 recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes. PMID: 19815544
U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII (EGFRvIII) mutant do not respond toirrradiation with 26s proteasome inhibition. PMID: 18337449
Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation. PMID: 19638347
the 26S proteasome may provide a general predictive biomarker for radiotherapy outcome. PMID: 19881955

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Protein Families

Proteasome subunit S2 family

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Database Links

HGNC: 9559

OMIM: 606223

KEGG: hsa:5708

STRING: 9606.ENSP00000310129

UniGene: Hs.518464

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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