PSME1 Antibody

Code CSB-PA018915DSR2HU
Size US$166
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  • Western blot
    All lanes: PSME1 antibody at 1.4μg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse thymus tissue
    Lane 3: Raji whole cell lysate
    Lane 4: HL60 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 29, 27 kDa
    Observed band size: 29, 25 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018915DSR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSME1 Polyclonal antibody
Uniprot No.
Target Names
PSME1
Alternative Names
11S regulator complex alpha subunit antibody; 11S regulator complex subunit alpha antibody; 29 kD MCP activator subunit antibody; 29kD MCP activator subunit antibody; Activator of multicatalytic protease subunit 1 antibody; IFI5111 antibody; IGUP I-5111 antibody; Interferon gamma IEF SSP 5111 antibody; Interferon gamma inducible protein 5111 antibody; Interferon gamma up regulated I 5111 protein antibody; Interferon gamma up-regulated I-5111 protein antibody; MGC8628 antibody; PA28a antibody; PA28alpha antibody; Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) antibody; Proteasome activator 28 subunit alpha antibody; Proteasome activator complex subunit 1 antibody; Proteasome activator subunit 1 antibody; PSME1 antibody; PSME1_HUMAN antibody; REG-alpha antibody; REGalpha antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Proteasome activator complex subunit 1 protein (1-249AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Gene References into Functions
  1. Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab PMID: 26944190
  2. Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival. PMID: 26892607
  3. Constitutive expression of PA28 and ERAP1 in melanoma cells indicate that both interfere with MART-1(26-35) epitope generation even in the absence of IFN-gamma PMID: 26399368
  4. PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID: 23918357
  5. Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNbeta in mouse pancreatic beta-cells. PMID: 23383295
  6. the first evidence of a novel ovarian cancer-specific marker PMID: 22532226
  7. PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. PMID: 12200048
  8. The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex. PMID: 14760793
  9. DJ-1 and PA28alpha may have roles in the onset of hepatocarcinogenesis PMID: 17671684
  10. the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer PMID: 17939699
  11. bortezomib-adapted HL-60 cells showed increased expression and proteasome association of the 11S proteasome activator PMID: 19225532

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Protein Families
PA28 family
Database Links

HGNC: 9568

OMIM: 600654

KEGG: hsa:5720

STRING: 9606.ENSP00000372155

UniGene: Hs.75348

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