PSTPIP1 Antibody

Code CSB-PA018944ESR2HU
Size US$166
Order now
Image
  • Western blot
    All lanes: PSTPIP1 antibody at 0.85 μg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Raw264.7 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 48, 46 kDa
    Observed band size: 48 kDa

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA018944ESR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSTPIP1 Polyclonal antibody
Uniprot No.
Target Names
PSTPIP1
Alternative Names
CD2 antigen binding protein 1 antibody; CD2 binding protein 1 antibody; CD2 cytoplasmic tail binding protein antibody; CD2-binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; H-PIP antibody; HPIP antibody; PAPAS antibody; PEST phosphatase interacting protein 1 antibody; PEST phosphatase-interacting protein 1 antibody; PPIP1_HUMAN antibody; Proline serine threonine phosphatase interacting protein 1 antibody; Proline-serine-threonine phosphatase-interacting protein 1 antibody; PSTPIP antibody; Pstpip1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
Gene References into Functions
  1. We identified HPIP protein expression as a novel independent poor prognostic indicator in cervical cancer PMID: 30033330
  2. Case Report: classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome with E250K mutation of PSTPIP1. PMID: 28628471
  3. HPIP expression is associated with high-grade ovarian tumors. PMID: 28039608
  4. we demonstrated that HPIP silencing suppressed TGF-beta1-induced EMT in lung cancer cells by inhibiting Smad2 activation. PMID: 28075456
  5. our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K/Akt signaling pathway. PMID: 27458096
  6. these structural variations in CD2BP1 gene due to the mutations could be one of the strongest reasons to demonstrate the involvement of these gene variations in the patients with rheumatoid arthritis. PMID: 27184502
  7. PSTPIP1 was found to interact with pyrin at the leading edge during cell migration. PMID: 26179737
  8. genetic polymorphism is associated with hyperzincemia and hypercalprotectinemia PMID: 26025129
  9. Molecular interactions between HPIP and FAK, and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics. PMID: 25486428
  10. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA syndrome. PMID: 24960411
  11. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors. PMID: 25040622
  12. PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation PMID: 24421327
  13. novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum PMID: 21790734
  14. non-mutated gene and pyoderma gangrenosum in IBD unresponsive to anakinra treatment PMID: 21438098
  15. The CCTG repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease. PMID: 19731031
  16. CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease PMID: 11971877
  17. PSTPIP1/CD2BP1 protein binds to pyrin PMID: 14595024
  18. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL PMID: 16204241
  19. CD2BP1 directly and negatively impacts T cell activation via isolated CD2 antigen triggering or T-cell receptor stimulation dependent on coordinate CD2 engagement. PMID: 16670297
  20. PSTPIP1 mutants require pyrin to induce formation of ASC pyroptosome, a molecular platform that recruits and activates caspase-1. PMID: 17964261
  21. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration PMID: 18480402
  22. These findings support the use of monogenic loci as candidates for investigating the genetic component of complex disease and provide preliminary evidence of association between SNPs in autoinflammatory genes and psoriatic JIA. PMID: 18576390
  23. demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein. ASC specks are associated with inflammasome activity PMID: 19584923
  24. PAPA syndrome occurs without identifiable mutation in CD2BB1 PMID: 19700023

Show More

Hide All

Involvement in disease
PAPA syndrome (PAPAS)
Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, uropodium. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cleavage furrow.
Tissue Specificity
Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta.
Database Links

HGNC: 9580

OMIM: 604416

KEGG: hsa:9051

STRING: 9606.ENSP00000452746

UniGene: Hs.129758

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*