PTBP2 Antibody, Biotin conjugated

1. It has been established that PTBP1 and PTBP2 are members of a family of cryptic exon repressors. PMID: 27681424
2. PTBP1 and PTBP2 impaired autoregulation of SRSF3 in oral squamous cell carcinoma cancer cells. PMID: 26416554
3. Data show that polypyrimidine tract-binding proteins nPTB and ROD1 interact with mitochondrial tRNA(Thr) in the cytoplasm outside of mitochondria. PMID: 26657638
4. In T98G glioma cells, the level of sumoylated PTBP2 was reduced compared to that of normal brain cells. Overall, this study shows that PTBP2 is posttranslationally modified by SUMO1. PMID: 24286314
5. MALAT1 binds to SFPQ releasing PTBP2 from the SFPQ/PTBP2 complex, the increased SFPQ-detached PTBP2 promotes cell proliferation and migration in colorectal cancer. PMID: 25025966
6. Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression. PMID: 24264039
7. Changes in miR-223/PTBP2 pathway could contribute of abnormal splicing in chronic myeloid leukemia. PMID: 23174904
8. Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. PMID: 21282112
9. present fluorescence, NMR, and in vivo splicing data in support of a role of PTB in inducing RNA loops. We show that the RNA recognition motifs (RRMs) 3 and 4 of PTB can bind two distant pyrimidine tracts and bring their 5' and 3' ends in close proximity PMID: 20160105
10. The nPTB proximal promoter, although rich in G+C content and presenting putative binding sites for the transcription factors Sp1, NF-1, NF-kB and Oct-1, lacks a typical TATA box. PMID: 16002244
11. Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433

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HGNC: 17662

OMIM: 608449

KEGG: hsa:58155

STRING: 9606.ENSP00000412788

UniGene: Hs.596061