PTPRN Antibody

1. E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories. PMID: 27881117
2. Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity. PMID: 26564179
3. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting. PMID: 26836020
4. The binding of CREB to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold. PMID: 25528004
5. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation. PMID: 25645784
6. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. PMID: 23396399
7. identification of cysteines that are critical for IA-2A binding of autoantibodies in patients with newly diagnosed type 1 diabetes PMID: 22966073
8. the IA-2A autoantibody response in children is intense with rapid maturation against immunogenic epitopes and a strong association with diabetes development PMID: 23110943
9. Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome. PMID: 21442164
10. analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain PMID: 21935384
11. ZnT8A, GADA and IA-2A are autoantibodies that may have a role in successful pancreas graft survival PMID: 21792090
12. In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies PMID: 21744463
13. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
14. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8. PMID: 21073664
15. Risk of autoantibody seroconversion among children followed in DPT-1 is age dependent PMID: 21270193
16. Data show that significantly increased expression of MCP-1, IL-2 and PTPR-N was observed in Tourette's syndrome cases. PMID: 20193755
17. T cells stimulated in vitro by the IA-2 epitope express IFN-gamma when restimulated by the similar rotavirus VP7 peptide. PMID: 20083660
18. Report a chimeric assay providing an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8 in type 1 diabetes mellitus. PMID: 20035758
19. ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. PMID: 11908951
20. Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay. PMID: 12021115
21. BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India. PMID: 12021127
22. findings indicate that glutamine at position 862, and residues 876-880 of the WPD loop of IA-2 are important for several of the IA-2 specific PTP domain epitopes PMID: 14624760
23. The islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic beta-cells. PMID: 15596545
24. Measuring IA-2A is useful for the diagnosis and prognosis of type 1 diabetes in Japanese. PMID: 15620435
25. IA-2 is an important regulator of dense core vesicle number and glucose-induced and basal insulin secretion in beta cells. PMID: 15939893
26. identification of proteins that interact with IA-2, the IA-2 interactome; the IA-2 interactome based on pull-down experiments, currently consists of 12 proteins; identification of these interacting proteins provides clues as to how IA-2 functions PMID: 16273344
27. Autoantibodies in type 1 diabetes for this protein provide a model for other autoimmune diseases. PMID: 18373080
28. HLA class II alleles strongly influence the prevalence of IA-2A in type 1 diabetes. PMID: 18504544
29. Inexpensive, nonradioactive method for the detection of autoantibodies cell-prepared PTPRN (also known as IA-2) in diabetics. PMID: 18535195
30. The study identifies a region of IA-2 frequently recognised by antibodies in Type 1 diabetes and demonstrates that these responses are associated with T-cells secreting IL-10 in response to a neighbouring determinant. PMID: 19447008

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HGNC: 9676

OMIM: 601773

KEGG: hsa:5798

STRING: 9606.ENSP00000295718

UniGene: Hs.89655