PTPRN

PTPRN, the protein tyrosine phosphatase non-receptor type, is alias PTP-N1, IA-2β, IA-2β, PTP-N, PTP1B, and so on. It is a protein encoded by the PTPRN gene, a member of the protein tyrosine phosphatase family, and is expressed predominantly in brain tissue, but also in other tissues such as the pancreas, spleen, skeletal muscle, and the heart.The mechanism of action of PTPRN involves its role as a phosphodiesterase that removes phosphoryl groups from protein tyrosine residues, thereby regulating cellular signaling, in particular, the insulin signaling pathway. The biological significance of PTPRN is mainly in its role in the regulation of cell signaling.

It is involved in the regulation of a variety of cellular processes, including cell growth, differentiation, migration, adhesion, and apoptosis, among other life activities.Abnormal function of PTPRN has been associated with the development of a variety of diseases, such as diabetes and tumors. In tumor cells, aberrant expression of PTPRN may be associated with malignant behaviors such as proliferation, migration and invasion of tumor cells . Therefore, PTPRN is a potential target in drug development and disease treatment.