PVRL3 Antibody

Code CSB-PA003390
Size US$100
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  • Western Blot analysis of A549 cells using Nectin 3 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
CD113 antibody; CDw113 antibody; DKFZP566B0846 antibody; FLJ90624 antibody; Nectin-3 antibody; Nectin3 antibody; Poliovirus receptor related 3 antibody; Poliovirus receptor related protein 3 antibody; Poliovirus receptor-like 3 antibody; Poliovirus receptor-related protein 3 antibody; PPR3 antibody; PRR3 antibody; Pvrl3 antibody; PVRL3_HUMAN antibody; PVRR3 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human Nectin 3.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Gene References into Functions
  1. Nectin-3 mutation in men with severe teratospermia PMID: 28689229
  2. Data suggest that 3 independent regions of TcdB (Clostridium difficile toxin B; 1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3. PMID: 26602083
  3. Expression of nectin-3 in pancreatic cancer can be a prognostic factor. PMID: 25690753
  4. PVRL3 is a physiologically relevant binding partner that can serve as a target for the prevention of TcdB-induced cytotoxicity in C. difficile infection. PMID: 26038560
  5. Nectin-3 is associated with the formation of cell junctions and be a putative suppressor molecule to the invasion of breast cancer cells. PMID: 24386110
  6. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
  7. Data suggest that expression of nectin-3 is up-regulated in eutopic endometrium of patients with endometriosis as compared with control subjects and up-regulated in all endometriotic lesions investigated compared with eutopic endometrium. PMID: 22926846

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Subcellular Location
Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
Protein Families
Nectin family
Tissue Specificity
Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
Database Links

HGNC: 17664

OMIM: 607147

KEGG: hsa:25945

STRING: 9606.ENSP00000418070

UniGene: Hs.293917

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