Phospho-ABL1 (Tyr412) Antibody

Datasheet
Code CSB-PA980598
Former Code(s) CSB-PA125884
Size US$360
Uniprot No. P00519
Image
  • Immunofluorescence staining of methanol-fixed HeLa cells using c-Abl (phospho-Tyr412) antibody.

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using c-Abl (phospho-Tyr412) antibody.

Raised in Rabbit
Species Reactivity Human, Mouse, Rat
Tested Applications ELISA, IHC, IF; IHC:1:50-1:100, IF:1:100-1:200
Form Liquid
Clonality Polyclonal
Alias ABL, JTK7, p150, c-ABL,
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Target Names ABL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717'
Involvement in disease Leukemia, chronic myeloid (CML); Congenital heart defects and skeletal malformations syndrome (CHDSKM)
Subcellular Location Cytoplasm, cytoskeleton, Nucleus, Mitochondrion, Note=Shuttles between the nucleus and cytoplasm depending on environmental signals, Sequestered into the cytoplasm through interaction with 14-3-3 proteins, Localizes to mitochondria in response to oxidative stress (By similarity), SUBCELLULAR LOCATION: Isoform IB: Nucleus membrane, Lipid-anchor
Protein Families Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
Tissue Specificity Widely expressed.
Database Links

HGNC: 76

OMIM: 189980

KEGG: hsa:25

STRING: 9606.ENSP00000361423

UniGene: Hs.431048

Pathway ErbB signaling pathway
Cell cycle
Ras signaling pathway
Neurotrophin signaling pathway

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