Phospho-ANAPC1 (S355) Antibody

1. Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC/C), represents a therapeutic target in myeloma. PMID: 27655696
2. in the Alzheimer's disease (AD)mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. PMID: 28505105
3. cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible PMID: 27601667
4. The ABBA-KEN-ABBA amino acid motif cassette holds the Mitotic Checkpoint Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC/C) by binding the two Cdc20 molecules in the MCC-APC/C complex. PMID: 27939943
5. findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. PMID: 26329581
6. Human Cytomegalovirus UL21a but not UL97 can disrupt APC/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1, in addition to the previously reported APC4 and APC5. PMID: 25903336
7. Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells. PMID: 23637229
8. EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact. PMID: 23263983
9. Single nucleotide polymorhpisms of ANAPC1 were associated with nicotine dependence. PMID: 22377092
10. Studies indicate that the APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint. PMID: 21633387
11. the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs PMID: 21454540
12. Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP. PMID: 21402913
13. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability. PMID: 19826416
14. Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients. PMID: 18535175
15. ANAPC1 methylation was probably not implicated in gastric carcinogenesis PMID: 18622497

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HGNC: 19988

OMIM: 608473

KEGG: hsa:64682

STRING: 9606.ENSP00000339109

UniGene: Hs.436527