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| Code | CSB-PA070118 |
| Size | US$167 |
| Uniprot No. | P22681 |
| Immunogen | Synthesized peptide derived from Human Cbl around the phosphorylation site of Y674. |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000 |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Alias | CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol |
| Target Names | CBL |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. |
| Involvement in disease | Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) |
| Subcellular Location | Cytoplasm, Cell membrane |
| Database Links |
HGNC: 1541 OMIM: 165360 KEGG: hsa:867 STRING: 9606.ENSP00000264033 UniGene: Hs.504096 |
| Pathway |
ErbB signaling pathway
T cell receptor signaling pathway Insulin signaling pathway Endocytosis |
CBL Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA205538 | Phospho-CBL (Tyr700) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA932513 | CBL (Ab-700) Antibody | Human | ELISA,WB,IHC |
| CSB-PA574497 | Phospho-CBL (Tyr674) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001340 | CBL Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA001352 | CBL Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA070119 | Phospho-CBL (Y774) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA070120 | Phospho-CBL (Y700) Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
| CSB-PA787303 | CBL Antibody | Human,Mouse | ELISA,WB |
| CSB-PA988596 | CBL Antibody | Human,Mouse | ELISA,WB |
| CSB-PA004578LB01HU | CBL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004578LC01HU | CBL Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004578LD01HU | CBL Antibody, Biotin conjugated | Human | ELISA |
CBL Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004578LA01HU | CBL Antibody | Human | ELISA, WB, IHC, IF |
CBL Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004578HU CSB-EP004578HU CSB-BP004578HU CSB-MP004578HU |
Recombinant Human E3 ubiquitin-protein ligase CBL(CBL) ,partial | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H4A (K31) Antibody
Applications: ELISA, WB, IF
Species Reactivity: Human, Rat
2-hydroxyisobutyryl-HIST1H4A (K8) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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