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Tel : 301-363-4651
Your Good Partner in Biology Research
| Code | CSB-PA070118 |
| Size | US$167 |
| Uniprot No. | P22681 | ||||||||
| Target Names | CBL | ||||||||
| Alternative Names | CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL | ||||||||
| Raised in | Rabbit | ||||||||
| Species Reactivity | Human,Mouse,Rat | ||||||||
| Immunogen | Synthesized peptide derived from Human Cbl around the phosphorylation site of Y674. | ||||||||
| Immunogen Species | Homo sapiens (Human) | ||||||||
| Conjugate | Non-conjugated | ||||||||
| Isotype | IgG | ||||||||
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
| Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||||
| Form | Liquid | ||||||||
| Tested Applications | WB, IHC, ELISA | ||||||||
| Recommended Dilution |
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| Protocols | Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol ELISA Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. | ||||||||
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. |
| Involvement in disease | Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL) |
| Subcellular Location | Cytoplasm, Cell membrane |
| Database Links |
HGNC: 1541 OMIM: 165360 KEGG: hsa:867 STRING: 9606.ENSP00000264033 UniGene: Hs.504096 |
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