E3 ubiquitin-protein ligase CBL is a protein in humans that is encoded by CBL gene. Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells.

CBL Antibodies

CBL Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA205538 Phospho-CBL (Tyr700) Antibody Human ELISA,WB,IHC,IF
CSB-PA932513 CBL (Ab-700) Antibody Human ELISA,WB,IHC
CSB-PA574497 Phospho-CBL (Tyr674) Antibody Human,Mouse,Rat ELISA,WB
CSB-PA001340 CBL Antibody Human,Mouse,Rat WB,IHC,IF,ELISA
CSB-PA001352 CBL Antibody Human,Mouse,Rat WB,IHC,ELISA
CSB-PA070118 Phospho-CBL (Y674) Antibody Human,Mouse,Rat WB,IHC,ELISA
CSB-PA070119 Phospho-CBL (Y774) Antibody Human,Mouse,Rat WB,IHC,IF,ELISA
CSB-PA070120 Phospho-CBL (Y700) Antibody Human,Mouse,Rat WB,IHC,IF,ELISA
CSB-PA787303 CBL Antibody Human,Mouse ELISA,WB
CSB-PA988596 CBL Antibody Human,Mouse ELISA,WB
CSB-PA004578LB01HU CBL Antibody, HRP conjugated Human ELISA
CSB-PA004578LC01HU CBL Antibody, FITC conjugated Human ELISA
CSB-PA004578LD01HU CBL Antibody, Biotin conjugated Human ELISA

CBL Antibodies for Human

Code Product Name Species Reactivity Application
CSB-PA004578LA01HU CBL Antibody Human ELISA, WB, IHC, IF


CBL cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL004578HU CBL pUC NM_005188.3


CBL ELISA Kit for Homo sapiens (Human)

Code Product Name Sample Types Sensitivity
CSB-EL004578HU Human E3 ubiquitin-protein ligase CBL(CBL) ELISA kit serum, plasma, tissue homogenates, cell lysates 6.25 pg/mL


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