Phospho-CD4 (S433) Antibody

Datasheet
Code CSB-PA070257
Size US$167
Uniprot No. P01730
Protocols Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human CD4 around the phosphorylation site of S433.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications IHC,IF,ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4
Immunogen Species Homo sapiens (Human)
Target Names CD4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells
Database Links

HGNC: 1678

OMIM: 186940

KEGG: hsa:920

STRING: 9606.ENSP00000011653

UniGene: Hs.631659

Pathway Antigen processing and presentation
Hematopoietic cell lineage
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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