Phospho-PPP1R14A (T38) Antibody

1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. PMID: 27793041
2. The authors call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase. PMID: 28387646
3. Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour. PMID: 27248983
4. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions PMID: 23800065
5. analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells PMID: 23583905
6. The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import. PMID: 23541585
7. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
8. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17. PMID: 22275376
9. RACK1 may play a role in PKC/CPI-17 signaling pathway. PMID: 20875397
10. cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA/Rock. PMID: 20202976
11. mapped to chromosome 19q13.13-q13.2 PMID: 11931393
12. CPI-17 binds directly to protein kinase C and casein kinase I. PMID: 15003508
13. importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise. PMID: 15234908
14. CPI-17 siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines PMID: 16885985
15. These data indicate that 14,15-epoxyeicosatrienoic acid hyperpolarizes airway smooth muscle cells and relaxes precontracted human bronchi and intracellular effects are related to a PKC-dependent process involving a lower phosphorylation level of CPI-17. PMID: 17237191
16. Human pregnancy is characterized by increases in PKN1 expression and PPP1R14A phosphorylation in the myometrium. PMID: 17301291
17. These results are consistent with a key molecular role for CPI-17 in airway hyperresponsiveness, in the absence of bronchial wall remodeling. PMID: 18757304
18. NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17. PMID: 18835652

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HGNC: 14871

OMIM: 608153

KEGG: hsa:94274

STRING: 9606.ENSP00000301242

UniGene: Hs.631569