Phospho-MEF2C (S387) Antibody

Datasheet
Code CSB-PA010170
Size US$167
Uniprot No. Q06413
Immunogen Synthesized peptide derived from Human MEF-2C around the phosphorylation site of S387.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications IHC,ELISA;IHC:1/100-1/300.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias MEF2C; Myocyte-specific enhancer factor 2C
Immunogen Species Homo sapiens (Human)
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names MEF2C
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Involvement in disease Mental retardation, autosomal dominant 20 (MRD20)
Subcellular Location Nucleus, Cytoplasm, sarcoplasm
Protein Families MEF2 family
Tissue Specificity Expressed in brain and skeletal muscle.
Database Links

HGNC: 6996

OMIM: 600662

KEGG: hsa:4208

UniGene: Hs.649965

Pathway MAPK signaling pathway
Apelin signaling pathway
cGMP-PKG signaling pathway

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