MEF2C Antibody

Datasheet
Code CSB-PA804958ESR1HU
Size US$167Purchase it in Cusabio online store
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Uniprot No. Q06413
Image
  • Western blot
    All lanes: MEF2C antibody at 1μg/ml + Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 52, 51, 48, 45, 53 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA804958ESR1HU at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Myocyte-specific enhancer factor 2C protein (170-380AA)
Raised in Rabbit
Species Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200
Relevance Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C), MEF2C
Immunogen Species Human
Research Area Signal Transduction
Target Names MEF2C
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Involvement in disease Mental retardation, autosomal dominant 20 (MRD20)
Subcellular Location Nucleus, Cytoplasm, sarcoplasm
Protein Families MEF2 family
Tissue Specificity Expressed in brain and skeletal muscle.
Database Links

HGNC: 6996

OMIM: 600662

KEGG: hsa:4208

UniGene: Hs.649965

Pathway MAPK signaling pathway
Apelin signaling pathway
cGMP-PKG signaling pathway

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