MEF2C (Ab-396) Antibody

Datasheet
Code CSB-PA961556
Product Type Polyclonal Antibody
Size US$297
Uniprot No. Q06413
Image
  • Western blot analysis of extracts from 3T3 cells, treated with starved (24hours), using MEF2C (Ab-396) antibody.
  • Western blot analysis of extracts from 3T3 cells (Lane 2), using MEF2C (Ab-396) antiobdy. The lane on the left is treated with synthesized peptide.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Synthesized non-phosphopeptide derived from Human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P).
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous levels of total MEF2C protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).
McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).
Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C;
Immunogen Species Homo sapiens (Human)
Target Names MEF2C
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Involvement in disease Mental retardation, autosomal dominant 20 (MRD20)
Subcellular Location Nucleus, Cytoplasm, sarcoplasm
Protein Families MEF2 family
Tissue Specificity Expressed in brain and skeletal muscle.
Database Links

HGNC: 6996

OMIM: 600662

KEGG: hsa:4208

UniGene: Hs.649965

Pathway MAPK signaling pathway
Apelin signaling pathway
cGMP-PKG signaling pathway

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