Phospho-MYF5 (S49) Antibody

1. Analysis of human rhabdomyosarcoma revealed that MYF5 and MYOD are mutually-exclusively expressed and each is required for sustained tumor growth. PMID: 28080960
2. Pitx2c expression is reactivated, while expression of Myf5 is downregulated in human systolic heart failure as determined by qRT-PCR and Western blot analyses. PMID: 24595098
3. results are the first demonstration of a myogenic conversion of human mesenchymal and endothelial cells by Myf5 PMID: 21810080
4. DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy PMID: 19829708
5. The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the muscle differentiation program. PMID: 12105204
6. Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis PMID: 12204280
7. Myogenin and myogenic differentiation factor D (MyoD) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 protein increased (P < 0.05) in both young and old. PMID: 16614355
8. A novel homozygous polymorphism that prevented the binding of MYF-5 to FOXE1 promoter and affected the FOXE1 expression was found in 45% nonsyndromic cleft palate. PMID: 19192046

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HGNC: 7565

OMIM: 159990

KEGG: hsa:4617

STRING: 9606.ENSP00000228644

UniGene: Hs.178023