Phospho-MYF5 (S49) Antibody

Code CSB-PA020000
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
bHLHc2 antibody; Class C basic helix loop helix protein 2 antibody; Class C basic helix-loop-helix protein 2 antibody; Myf 5 antibody; Myf-5 antibody; Myf5 antibody; MYF5_HUMAN antibody; Myogenic factor 5 antibody
Raised in
Species Reactivity
Synthesized peptide derived from Human Myf-5 around the phosphorylation site of S49.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Gene References into Functions
  1. Analysis of human rhabdomyosarcoma revealed that MYF5 and MYOD are mutually-exclusively expressed and each is required for sustained tumor growth. PMID: 28080960
  2. Pitx2c expression is reactivated, while expression of Myf5 is downregulated in human systolic heart failure as determined by qRT-PCR and Western blot analyses. PMID: 24595098
  3. results are the first demonstration of a myogenic conversion of human mesenchymal and endothelial cells by Myf5 PMID: 21810080
  4. DUX4c induces the MYF5 protein and myoblast proliferation, and has a role in facioscapulohumeral muscular dystrophy PMID: 19829708
  5. The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the muscle differentiation program. PMID: 12105204
  6. Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis PMID: 12204280
  7. Myogenin and myogenic differentiation factor D (MyoD) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 protein increased (P < 0.05) in both young and old. PMID: 16614355
  8. A novel homozygous polymorphism that prevented the binding of MYF-5 to FOXE1 promoter and affected the FOXE1 expression was found in 45% nonsyndromic cleft palate. PMID: 19192046

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Subcellular Location
Database Links

HGNC: 7565

OMIM: 159990

KEGG: hsa:4617

STRING: 9606.ENSP00000228644

UniGene: Hs.178023

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