RAB23 Antibody

Datasheet

Code	CSB-PA891960ESR1HU
Size	US$166
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Image	Western blot All lanes: RAB23 antibody at 3.88μg/ml Lane 1: Mouse ocular tissue Lane 2: Rat brain tissue Lane 3: Mouse kidney tissue Lane 4: Mouse lung tissue Lane 5: Mouse brain tissue Lane 6: NIH/3T3 whole cell lysate Lane 7: MCF-7 whole cell lysate Lane 8: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 27 kDa Observed band size: 27 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA891960ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA891960ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB23 Polyclonal antibody

Uniprot No.

Q9ULC3

Target Names

RAB23

Alternative Names

DKFZp781H0695 antibody; HSPC137 antibody; MGC8900 antibody; Rab 23 antibody; RAB family small GTP binding protein RAB 23 antibody; Rab23 antibody; RAB23; member RAS oncogene family antibody; RAB23_HUMAN antibody; Ras related protein Rab 23 antibody; Ras-related protein Rab-23 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Ras-related protein Rab-23 protein (1-237AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO's product CSB-PA891960ESR1HU is a polyclonal antibody raised in the rabbit against a peptide mapping within amino acids 1-237 of the human RAB23 protein. This RAB23 antibody occurs as an unconjugated IgG. Purification by antigen affinity method reaches a relatively high purity. It is reactive to human, mouse, and rat samples. And it has been demonstrated to recognize RAB23 protein in the ELISA, WB, and IHC applications. Its target protein RAB23 is a small GTPase that exerts important development functions in vertebrates and regulates Sonic hedgehog (Shh) and Nodal signaling.

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Target Background

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.

Gene References into Functions

Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. PMID: 29416296
miR-429 was down-regulated in hepatocellular carcinoma (HCC) tissues and cells. Up regulation of miR-429 decreased the migratory capacity and reversed the EMT to MET in HCC cells. RAB23 was confirmed as a target of miR-429. PMID: 29191386
Down-regulation of Rab23 suppressed the proliferation, migration and invasion of prostate cancer cells. PMID: 28277196
Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity PMID: 26897750
High Rab23 expression is associated with bladder cancer. PMID: 26715272
Forced expression of MiR-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target PMID: 27659550
Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1. PMID: 26648292
Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression PMID: 26238143
Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis. PMID: 25867419
Rab23 was a target gene of miR-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR-367. PMID: 25489984
The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1. PMID: 23007279
Rab23 expression level was the highest in Bcap-37 cells. PMID: 23948406
Rab9A and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus. PMID: 22452336
association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component PMID: 21540310
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay PMID: 21412941
A RAB23 mutation (c.86dupA) present in the homozygote state in four relatives of Comorian origin with Carpenter syndrome, is reported. PMID: 20358613
Rab23 is overexpressed and/or activated in hepatocellular carcinoma (HCC). Rab23 may be both a HCC predictor and a target for treating HCC. PMID: 17373734
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development. PMID: 17503333
Data show that RAB23 participates in central nervous system development. PMID: 18485483
RAB23 amplifications are associated with gastric cancer PMID: 18559507

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Involvement in disease

Carpenter syndrome 1 (CRPT1)

Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Small GTPase superfamily, Rab family

Database Links

HGNC: 14263

OMIM: 201000

KEGG: hsa:51715

STRING: 9606.ENSP00000320413

UniGene: Hs.555016

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The Overview of Organelles Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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