RBL1 Antibody

Datasheet
Code CSB-PA019398GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P28749
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human RBL1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias retinoblastoma-like 1 (p107);RBL1;CP107;MGC40006;PRB1;p107 ;
Immunogen Species Homo sapiens (Human)
Target Names RBL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that This protein may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
HGNC 9893
RGD 1595511
MGI 103300
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Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Subcellular Location Nucleus
Protein Families Retinoblastoma protein (RB) family
Database Links

HGNC: 9893

OMIM: 116957

KEGG: hsa:5933

STRING: 9606.ENSP00000362768

UniGene: Hs.207745

Pathway TGF-beta signaling pathway
Cell cycle
Cellular senescence

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