Retinoblastoma-like protein 1 is a protein in humans that is encoded by RBL1 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
RBL1 Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
|CSB-PA040182||Phospho-RBL1 (T369) Antibody||Human,Mouse||IHC,ELISA|
|CSB-PA019398LA01HU||RBL1 Antibody||Human, Mouse||ELISA, WB|
|CSB-PA019398LB01HU||RBL1 Antibody, HRP conjugated||Human||ELISA|
|CSB-PA019398LC01HU||RBL1 Antibody, FITC conjugated||Human||ELISA|
|CSB-PA019398LD01HU||RBL1 Antibody, Biotin conjugated||Human||ELISA|
RBL1 Proteins for Homo sapiens (Human)
|Recombinant Human Retinoblastoma-like protein 1(RBL1) ,partial|| Yeast
RBL1 Proteins for Mus musculus (Mouse)
|Recombinant Mouse Retinoblastoma-like protein 1(Rbl1) ,partial|| Yeast
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