RBL1 Antibody

Datasheet
Code CSB-PA040183
Size US$167
Uniprot No. P28749
Protocols Immunofluorescence (IF) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from Human p107 around the non-phosphorylation site of T369.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications IF,ELISA;IF:1/200-1/1000.ELISA:1/5000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias RBL1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1
Immunogen Species Homo sapiens (Human)
Target Names RBL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Subcellular Location Nucleus
Protein Families Retinoblastoma protein (RB) family
Database Links

HGNC: 9893

OMIM: 116957

KEGG: hsa:5933

STRING: 9606.ENSP00000362768

UniGene: Hs.207745

Pathway TGF-beta signaling pathway
Cell cycle
Cellular senescence

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