RDH11 Antibody

Datasheet

Code	CSB-PA019523LA01HU
Size	US$166
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Image	Western blot All lanes: RDH11 antibody at 10µg/ml Lane 1: PC-3 whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 35, 28 kDa Observed band size: 36 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019523LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA019523LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RDH11 Polyclonal antibody

Uniprot No.

Q8TC12

Target Names

RDH11

Alternative Names

Androgen regulated short chain dehydrogenase/reductase 1 antibody; Androgen-regulated short-chain dehydrogenase/reductase 1 antibody; ARSDR1 antibody; AU045252 antibody; C85936 antibody; CGI 82 antibody; FLJ32633 antibody; HCBP12 antibody; HCV core binding protein antibody; HCV core binding protein HCBP12 antibody; HCV core-binding protein HCBP12 antibody; MDT1 antibody; Prostate short chain dehydrogenase/reductase 1 antibody; Prostate short-chain dehydrogenase/reductase 1 antibody; PSDR1 antibody; RALR1 antibody; RDH11 antibody; RDH11_HUMAN antibody; Retinal reductase 1 antibody; retinol dehydrogenase 11 (all trans/9 cis/11 cis) antibody; Retinol dehydrogenase 11 antibody; SCALD antibody; SDR7C1 antibody; Short chain dehydrogenase/reductase family 7C; member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Retinol dehydrogenase 11 protein (22-318AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RDH11 Antibody (Product code: CSB-PA019523LA01HU) is Non-conjugated. For RDH11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA019523LB01HU	RDH11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019523LC01HU	RDH11 Antibody, FITC conjugated
Biotin	CSB-PA019523LD01HU	RDH11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal. Has no dehydrogenase activity towards steroid.

Gene References into Functions

Data suggest that membrane anchoring of retinol dehydrogenase 11 (RDH11) is likely driven by its N-terminal segment. PMID: 25542782
Data indicate that ribosomal protein L11 (RPL11)-expressing cells proliferated more rapidly than the ribosomal protein L11 (RPL11)-expressing cells. PMID: 25829192
deleterious mutations in RDH11, an important enzyme for vision-related and systemic retinoic acid metabolism, cause a new syndrome with RP. PMID: 24916380
Prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). PMID: 12036956
The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV. PMID: 12532453
Expression pattern and high catalytic efficiency of RalR1 are consistent with the hypothesis that RalR1 contributes to the reduction of retinal in various human tissues. PMID: 14674758
RDH11 localizes to photoreceptor inner segments [review] PMID: 17249616

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Involvement in disease

Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS)

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Tissue Specificity

Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and f

Database Links

HGNC: 17964

OMIM: 607849

KEGG: hsa:51109

STRING: 9606.ENSP00000370750

UniGene: Hs.719925

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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