RFX5 Antibody

Code CSB-PA019614GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RFX5
Alternative Names
DNA binding protein RFX 5 antibody; DNA binding protein RFX5 antibody; DNA-binding protein RFX5 antibody; Influences HLA class II expression antibody; Regulatory factor X 5 antibody; Regulatory factor X subunit 5 antibody; Regulatory factor X; 5 (influences HLA class II expression) antibody; RFX 5 antibody; RFX5 antibody; Rfx5 protein antibody; RFX5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human RFX5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
Gene References into Functions
  1. RFX5 acts as a direct positive transcriptional regulator of TPP1 in hepatocellular carcinoma. PMID: 27840983
  2. Data show arginine methyltransferase PRMT6 methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression. PMID: 23911394
  3. these data have identified as novel pathway whereby SIRT1 maintains COL1A2 synthesis in SMCs by modulating RFX5 activity. PMID: 23079621
  4. RFXAP(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple. PMID: 20732328
  5. interaction at COL1A2 start site and transcription repression PMID: 11986307
  6. The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function. PMID: 12368908
  7. RFX5 binds to the collagen transcription start site and represses collagen gene expression PMID: 12968017
  8. The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression. PMID: 15210800
  9. RFXAP and RFXB have roles in relieving autoinhibition of RFX5 PMID: 18723135
  10. TSA treatment enhances the association of CIITA with the transcription factor RFX5, which ameliorates the down-regulation of CIITA recruitment to target promoters by HDAC2. PMID: 19041327

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Involvement in disease
Bare lymphocyte syndrome 2 (BLS2)
Subcellular Location
Nucleus.
Protein Families
RFX family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 9986

OMIM: 209920

KEGG: hsa:5993

STRING: 9606.ENSP00000290524

UniGene: Hs.632472

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