Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA313364LA01HU |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Full Product Name | Rabbit anti-Homo sapiens (Human) C4B Polyclonal antibody | ||||
| Uniprot No. | P0C0L5 | ||||
| Target Names | C4B | ||||
| Alternative Names | Basic complement C4 antibody; C2B5 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody; C4b antibody; C4B1 antibody; C4B2 antibody; C4B3 antibody; CO4B_HUMAN antibody; Complement C4 gamma chain antibody; Complement component 4B antibody; CPAMD3 antibody | ||||
| Raised in | Rabbit | ||||
| Species Reactivity | Human | ||||
| Immunogen | Recombinant Human Complement C4-B protein (1454-1744AA) | ||||
| Immunogen Species | Homo sapiens (Human) | ||||
| Conjugate | Non-conjugated The C4B Antibody (Product code: CSB-PA313364LA01HU) is Non-conjugated. For C4B Antibody with conjugates, please check the following table. |
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| Clonality | Polyclonal | ||||
| Isotype | IgG | ||||
| Purification Method | >95%, Protein G purified | ||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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| Form | Liquid | ||||
| Tested Applications | ELISA, IHC | ||||
| Recommended Dilution |
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| Protocols | ELISA Protocol Immunohistochemistry (IHC) Protocol |
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| Troubleshooting and FAQs | Antibody FAQs | ||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
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| Involvement in disease | Systemic lupus erythematosus (SLE); Complement component 4B deficiency (C4BD) |
| Subcellular Location | Secreted. Cell junction, synapse. Cell projection, axon. Cell projection, dendrite. |
| Tissue Specificity | Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extr |
| Database Links |
HGNC: 1324 OMIM: 120820 KEGG: hsa:100293534 STRING: 9606.ENSP00000415941 UniGene: Hs.534847 |
