MCHR1 Antibody

Code CSB-PA132314
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Human fetal liver tissue, Human testis tissue, 293T cells, A172 cells, mouse brain tissue, human fetal brain tissue, Primary antibody: CSB-PA132314(MCHR1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
Alternative Names
MCHR1; GPR24; SLC1; Melanin-concentrating hormone receptor 1; MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human MCHR1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Gene References into Functions
  1. Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors. PMID: 24305679
  2. results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment PMID: 22081064
  3. SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China. PMID: 22154049
  4. DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription. PMID: 21637341
  5. two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling PMID: 20833795
  6. MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin. PMID: 20888736
  7. data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo PMID: 20633139
  8. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. PMID: 11839762
  9. MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells. PMID: 12127971
  10. MCHR1 is expressed and functional in human skin PMID: 12176038
  11. MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. PMID: 12220661
  12. study demonstrates a complex interaction between melanin concentrating hormone receptor 1 and Gs protein-coupled signaling pathways PMID: 12865333
  13. multiple antibody binding sites on melanin-concentrating hormone receptor 1 in vitiligo, including regions between amino acids 1 to 138 and 139 to 298. PMID: 14632194
  14. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
  15. a single point mutation at position 255 (T255A), which is located at the junction of intracellular loop 3 and transmembrane domain 6, reduces the MCHR1 cell surface expression level to 20% of that observed for the wild-type receptor PMID: 15928315
  16. Association of MCHR1 alleles/haplotype detected might be related to juvenile-onset obesity, conditional on a particular genetic and/or environmental background. PMID: 15941924
  17. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
  18. study suggests that severe forms of obesity with early onset may be associated with single nucleotide polymorphisms in melanin-concentrating hormone receptor 1 (MCHR1) PMID: 16186414
  19. Study suggest that GPR24 variants may confer susceptibility to both bipolar affective disorder and schizophrenia. PMID: 16741940
  20. Single nucleotide polymorphisms of MCHR1 did not have effects on metabolic variables in humans. PMID: 18198296
  21. These data suggest that a functional interaction between MCHR1 and caveolin-1 in lipid rafts exists and provide a basis for further biochemical studies to understand the significance on MCH-mediated signal transduction events. PMID: 18722347
  22. analysis of epitope specificity of MCHR1 antibodies PMID: 19320743
  23. The 10-amino-acid cyclic core of the hMCH neuropeptide with the Arg attached to the N-terminus of the disulfide ring is sufficient for full activation of melanin-concentrating hormone receptor 1. PMID: 11478907

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
Database Links

HGNC: 4479

OMIM: 601751

KEGG: hsa:2847

STRING: 9606.ENSP00000249016

UniGene: Hs.248122

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