SEMA7A Antibody

Code CSB-PA001418
Size US$167
Image
  • Western Blot analysis of Jurkat cells using CD108 Polyclonal Antibody
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Product Details

Uniprot No. O75326
Target Names SEMA7A
Alternative Names CD 108 antibody; CD108 antibody; CD108 antigen antibody; CDw108 antibody; H Sema K1 antibody; H Sema L antibody; H-SEMA-K1 antibody; H-Sema-L antibody; JMH antibody; JMH blood group antigen antibody; John Milton Hagen blood group H Sema K1 antibody; John Milton Hargen human blood group Ag antibody; John-Milton-Hargen human blood group Ag antibody; MGC126692 antibody; MGC126696 antibody; SEM7A_HUMAN antibody; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A antibody; Sema K1 antibody; Sema L antibody; SEMA7A antibody; SEMAK1 antibody; SEMAL antibody; Semaphorin 7A GPI membrane anchor antibody; Semaphorin K1 antibody; Semaphorin L antibody; Semaphorin-7A antibody; Semaphorin-K1 antibody; Semaphorin-L antibody; Semaphorin7a antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human CD108.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Gene References into Functions
  1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis PMID: 28109308
  2. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor PMID: 27065336
  3. Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals PMID: 28336906
  4. Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS. PMID: 26432853
  5. SEMA7A has a role in the development of lung injury PMID: 26752048
  6. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21. PMID: 26597008
  7. These results suggest that SEMA7a plays a role as a CSF biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients PMID: 25406498
  8. heterozygous missense variants in SEMA3A and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder PMID: 24522099
  9. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans. PMID: 23850082
  10. Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma. PMID: 24333536
  11. two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer PMID: 23166499
  12. Semaphorin 7A protein variants differentially regulate T-cell activity. PMID: 22845496
  13. Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells. PMID: 22448926
  14. We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia. PMID: 22891341
  15. Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8 PMID: 21524887
  16. A new SEMA7A variant was identified in Native American plasma samples, and an alloantibody that recognizes the wild-type protein PMID: 20854351
  17. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers. PMID: 20727575
  18. Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes PMID: 12193228
  19. SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex. PMID: 15907379
  20. Polymorphisms in SEMA7A may play a role in decreased bone mineral density and increased risk of vertebral fracture. PMID: 16372136
  21. beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation. PMID: 17671519
  22. Sema7A binds to human melanocytes through beta1-integrins and the Plexin C1 receptor PMID: 19318806

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Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor, Extracellular side
Protein Families Semaphorin family
Tissue Specificity Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus
Database Links

HGNC: 10741

OMIM: 607961

KEGG: hsa:8482

STRING: 9606.ENSP00000261918

UniGene: Hs.24640

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