SIGLEC7 Antibody

1. Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome. PMID: 28378743
2. NK cells with Siglec-7neg phenotype possess a high and sustainable killing activity and have the capability to eliminate a NK-resistant leukemia cell and hypersialylated tumor cells PMID: 29617289
3. CD56bright NK cells from obese subjects had a reduced expression of Siglec-7 PMID: 28786023
4. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities. PMID: 27312286
5. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils. PMID: 24810846
6. These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages. PMID: 24330394
7. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity. PMID: 24569453
8. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis. PMID: 22933622
9. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition. PMID: 23029261
10. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. PMID: 11774609
11. high resolution crystal structures of this protein; insights into ligand specificity of this family of proteins PMID: 12438315
12. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells. PMID: 12778482
13. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1 PMID: 14747738
14. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity PMID: 15292262
15. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2. PMID: 15557178
16. upon pervanadate (PV) treatment, Siglec-7 recruited the protein tyrosine phosphatases Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase-1 and SHP-2 less efficiently than did other inhibitory receptors PMID: 15703304
17. structural analysis of siglec-7 in complex with sialosides PMID: 16623661
18. Siglecs-7 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
19. The expression levels of Siglec-7 were detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
20. The species-specific differences in the expression expression of Siglecs in SIV infection was studied. PMID: 18331725
21. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. PMID: 19710502

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HGNC: 10876

OMIM: 604410

KEGG: hsa:27036

STRING: 9606.ENSP00000323328

UniGene: Hs.655393