SIGLEC7 Antibody, FITC conjugated

Code CSB-PA896485LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SIGLEC7 Polyclonal antibody
Uniprot No.
Target Names
SIGLEC7
Alternative Names
Adhesion inhibitory receptor molecule 1 antibody; Adhesion inhibitory receptor molecule 1, siglec 7 antibody; AIRM 1 antibody; AIRM-1 antibody; AIRM1 antibody; CD328 antibody; CD328 antigen antibody; CDw328 antibody; D siglec antibody; D-siglec antibody; HLDA 8 antibody; p75 antibody; p75/AIRM1 antibody; QA79 antibody; QA79 membrane protein antibody; Sialic acid binding Ig like lectin 7 antibody; Sialic acid binding immunoglobulin like lectin 7 antibody; Sialic acid-binding Ig-like lectin 7 antibody; SIGL7_HUMAN antibody; Siglec-7 antibody; SIGLEC19P antibody; SIGLEC7 antibody; SIGLECP2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sialic acid-binding Ig-like lectin 7 protein (377-467AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Gene References into Functions
  1. Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome. PMID: 28378743
  2. NK cells with Siglec-7neg phenotype possess a high and sustainable killing activity and have the capability to eliminate a NK-resistant leukemia cell and hypersialylated tumor cells PMID: 29617289
  3. CD56bright NK cells from obese subjects had a reduced expression of Siglec-7 PMID: 28786023
  4. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities. PMID: 27312286
  5. Siglec-7 plays a significant role in inhibiting IgE-mediated mast cell activation, but only moderately affects IgE-mediated activation in primary human basophils. PMID: 24810846
  6. These results show that Siglec-7 binds HIV-1 via gp120 and contributes to enhance the susceptibility to infection of CD4 positive T cells and monocyte-derived macrophages. PMID: 24330394
  7. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity. PMID: 24569453
  8. Based on upregulated SIGLEC7 expression in blood monocytes during relapse, findings suggest a role for SIGLEC7 in acute disease activity in multiple sclerosis. PMID: 22933622
  9. Siglec-7 participates in generating a monocyte-mediated inflammatory outcome following pathogen recognition. PMID: 23029261
  10. Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. PMID: 11774609
  11. high resolution crystal structures of this protein; insights into ligand specificity of this family of proteins PMID: 12438315
  12. Sialidase unmasking of siglec-7 on NK cells permits it to interact with GD3 on target cells and inhibit killing. This has inplications for tumor escape from NK cells. PMID: 12778482
  13. x-ray crystallographic analysis of the saccharide-binding domain of p75/AIRM1 PMID: 14747738
  14. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity PMID: 15292262
  15. Siglec-7 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2. PMID: 15557178
  16. upon pervanadate (PV) treatment, Siglec-7 recruited the protein tyrosine phosphatases Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase-1 and SHP-2 less efficiently than did other inhibitory receptors PMID: 15703304
  17. structural analysis of siglec-7 in complex with sialosides PMID: 16623661
  18. Siglecs-7 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
  19. The expression levels of Siglec-7 were detectable in bone marrow plasma from AML patients and serum from normal donors. PMID: 16828866
  20. The species-specific differences in the expression expression of Siglecs in SIV infection was studied. PMID: 18331725
  21. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. PMID: 19710502

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Tissue Specificity
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
Database Links

HGNC: 10876

OMIM: 604410

KEGG: hsa:27036

STRING: 9606.ENSP00000323328

UniGene: Hs.655393

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