SLC28A2 Antibody

1. results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs, revealed extended conformationally mobile regions within transport-domain TMs, identified pore-lining residues of functional importance, and provided evidence of an emerging novel elevator-type mechanism of transporter function. PMID: 28385889
2. association between ribavirin (RBV) serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response PMID: 23195617
3. genetic association studies in population in Italy: Data suggest that 3 SNPs (SLC28A2 rs11854484; IL28B, rs8099917; CYP27B1, rs4646536) are associated with pharmacokinetics of ribavirin and thus, sustained virologic response in hepatitis C patients. PMID: 23149444
4. These findings support the theory that CNT2 plays roles other than salvage and establishes links with energy metabolism. PMID: 20506327
5. there are notable species differences in the specificity of SPNT for synthetic nucleoside analogs. PMID: 12110519
6. Characterization of sodium-dependent nucleoside transporter hCNT2 cloned from duodenum. PMID: 12893280
7. Human nucleoside transporters involved in cellular uptake of Bbenzamide riboside and tiazofurin and their role in cytotoxicity. PMID: 15486050
8. analysis of polymorphisms in the human concentrative nucleoside transporter, CNT2 PMID: 15861032
9. Results identify the critical domains and amino acid residues that contribute to the observed difference in specificity between concentrative nucleoside transporter (CNT)2 orthologs. PMID: 16840788
10. HNF4alpha is a major determinant of SLC28A1 expression, whereas C/EBPalpha and HNF3gamma modulate SLC28A2 gene expression. PMID: 17187757
11. hCNT2 shares common cation specificity and coupling characteristics with hCNT1, which differ markedly from those of hCNT3. PMID: 17453413
12. This study shows that adenosine elimination on human airway epithelia is mediated by ADA1, CNT2, and CNT3, which constitute important regulators of adenosine-mediated inflammation. PMID: 17696452
13. Five novel nonsynonymous variants (L12R, R142H, E172D, E385K, M612T) expressed in U-251 cells revealed that all except E385K can uptake various substrates of CNT2: inosine, ribavirin and uridine. PMID: 17700367
14. These data suggest that selected genes of the SLC28 and SLC29 families are not only targets of HIV-1 infection, but might also contribute to the development of adipose tissue alterations leading to lipodystrophy. PMID: 17926640
15. Report expression and hepatobiliary transport characteristics of CNT2 in sandwich-cultured human hepatocytes. PMID: 18635603
16. Single nucleotide polymorphisms of this protein may play a role in variation in the pharmacokinetics and pharmacological effects of nucleoside analogs. PMID: 19098160
17. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20028759

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HGNC: 11002

OMIM: 606208

KEGG: hsa:9153

STRING: 9606.ENSP00000315006

UniGene: Hs.367833