SLC6A3 Antibody

Datasheet
Code CSB-PA791171
Size US$299
Uniprot No. Q01959
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA791171(SLC6A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA791171(SLC6A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human SLC6A3
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:2000-1:5000,IHC:1:50-1:200
Relevance This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias solute carrier family 6 (neurotransmitter transporter), member 3
Immunogen Species Homo sapiens (Human)
Target Names SLC6A3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Involvement in disease Parkinsonism-dystonia infantile (PKDYS)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A3 subfamily
Tissue Specificity Highly expressed in substantia nigra.
Database Links

HGNC: 11049

OMIM: 126455

KEGG: hsa:6531

STRING: 9606.ENSP00000270349

UniGene: Hs.406

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