The SLC6A3 gene encodes the dopamine transporter, a member of the sodium and chloride-dependent neurotransmitter transporter family. Structurally, it consists of 12 transmembrane domains and exhibits specific glycosylation characteristics. The dopamine transporter is primarily responsible for the transport and reuptake of dopamine, thereby precisely regulating its concentration in the synaptic cleft and influencing neural signal transmission. Additionally, the 3'UTR of the SLC6A3 gene contains a variable number tandem repeat sequence, and variations in the number of repeats are associated with the risk of developing various neurological and psychiatric disorders. In terms of signaling pathways, the dopamine transporter indirectly affects dopamine receptor-mediated signaling processes by modulating dopamine concentrations. Abnormal function of the dopamine transporter may lead to disruptions in neural signal transmission, ultimately triggering related diseases.
Validated Data
Positive WB detected in: Mouse brain tissue
All lanes: SLC6A3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA021701LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following SLC6A3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SLC6A3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA198930 | SLC6A3 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA791171 | SLC6A3 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA021701LA01HU | SLC6A3 Antibody |
Human, Mouse | ELISA, WB, IF |
CSB-PA021701LB01HU | SLC6A3 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA021701LC01HU | SLC6A3 Antibody, FITC conjugated |
Human | |
CSB-PA021701LD01HU | SLC6A3 Antibody, Biotin conjugated |
Human | ELISA |