SMAD9 Antibody

Code CSB-PA022161
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA022161(SMAD9 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
SMAD9
Alternative Names
MAD homolog 9 antibody; Madh6 antibody; Mothers against decapentaplegic antibody; Mothers against decapentaplegic homolog 9 antibody; Mothers against DPP homolog 9 antibody; SMAD 9 antibody; SMAD family member 9 antibody; SMAD, mothers against DPP homolog 9 (Drosophila) antibody; SMAD8A antibody; SMAD8B antibody; Smad9 antibody; SMAD9_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human SMAD9
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Gene References into Functions
  1. Our results exclude a significant role for the SMAD9v90m mutation in juvenile polyposis syndrome PMID: 28424237
  2. Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension. PMID: 28582316
  3. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID: 26748560
  4. Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression. PMID: 26122142
  5. ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad8 PMID: 23384547
  6. CREBZF, a novel Smad8-binding protein. PMID: 22707059
  7. Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH. PMID: 19211612

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Involvement in disease
Pulmonary hypertension, primary, 2 (PPH2)
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Dwarfin/SMAD family
Tissue Specificity
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
Database Links

HGNC: 6774

OMIM: 603295

KEGG: hsa:4093

STRING: 9606.ENSP00000369154

UniGene: Hs.123119

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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