SMC1B Antibody

Datasheet

Code	CSB-PA854104LA01HU
Size	US$166
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Image	IHC image of CSB-PA854104LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA854104LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMC1B Polyclonal antibody

Uniprot No.

Q8NDV3

Target Names

SMC1B

Alternative Names

bK268H5 antibody; SMC protein 1B antibody; SMC-1-beta antibody; SMC-1B antibody; SMC1 beta antibody; SMC1B antibody; SMC1B_HUMAN antibody; SMC1beta antibody; SMC1beta protein antibody; Smc1l2 antibody; Structural maintenance of chromosomes 1-like 2 antibody; Structural maintenance of chromosomes 1B antibody; Structural maintenance of chromosomes protein 1B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SMC1B Antibody (Product code: CSB-PA854104LA01HU) is Non-conjugated. For SMC1B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA854104LB01HU	SMC1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA854104LC01HU	SMC1B Antibody, FITC conjugated
Biotin	CSB-PA854104LD01HU	SMC1B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.

Gene References into Functions

Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility. PMID: 28364521
Data show that structural maintenance of chromosomes protein 1B (SMC1B) is expressed in primary fibroblasts. PMID: 26673124
High SMC1B expression is associated with pancreatic cancer. PMID: 25216700

Subcellular Location

Nucleus. Chromosome. Chromosome, centromere.

Protein Families

SMC family, SMC1 subfamily

Database Links

HGNC: 11112

OMIM: 608685

KEGG: hsa:27127

STRING: 9606.ENSP00000350036

UniGene: Hs.334176

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Cell cycle

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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