SMC1B Antibody, HRP conjugated

Code CSB-PA854104LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SMC1B Polyclonal antibody
Uniprot No.
Target Names
SMC1B
Alternative Names
bK268H5 antibody; SMC protein 1B antibody; SMC-1-beta antibody; SMC-1B antibody; SMC1 beta antibody; SMC1B antibody; SMC1B_HUMAN antibody; SMC1beta antibody; SMC1beta protein antibody; Smc1l2 antibody; Structural maintenance of chromosomes 1-like 2 antibody; Structural maintenance of chromosomes 1B antibody; Structural maintenance of chromosomes protein 1B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Gene References into Functions
  1. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility. PMID: 28364521
  2. Data show that structural maintenance of chromosomes protein 1B (SMC1B) is expressed in primary fibroblasts. PMID: 26673124
  3. High SMC1B expression is associated with pancreatic cancer. PMID: 25216700
Subcellular Location
Nucleus. Chromosome. Chromosome, centromere.
Protein Families
SMC family, SMC1 subfamily
Database Links

HGNC: 11112

OMIM: 608685

KEGG: hsa:27127

STRING: 9606.ENSP00000350036

UniGene: Hs.334176

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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