SMC1B Antibody, Biotin conjugated

Datasheet
Code CSB-PA854104LD01HU
Size US$299
Uniprot No. Q8NDV3
Protocols ELISA Protocol
Immunogen Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B), SMC1B, SMC1L2
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names SMC1B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Subcellular Location Nucleus, Chromosome, Chromosome, centromere
Protein Families SMC family, SMC1 subfamily
Database Links

HGNC: 11112

OMIM: 608685

KEGG: hsa:27127

STRING: 9606.ENSP00000350036

UniGene: Hs.334176

Pathway Cell cycle

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