SNX10 Antibody, HRP conjugated

Code CSB-PA896538LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNX10 Polyclonal antibody
Uniprot No.
Target Names
SNX10
Alternative Names
2410004M09Rik antibody; MGC109202 antibody; MGC33054 antibody; OPTB8 antibody; SNX10 antibody; SNX10_HUMAN antibody; Sorting nexin 10 antibody; Sorting nexin-10 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sorting nexin-10 protein (124-201AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
Gene References into Functions
  1. supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis PMID: 25811986
  2. Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis patients) affects protein-protein interactions of SNX10. PMID: 25212774
  3. results confirm the involvement of the SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases PMID: 23280965
  4. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. PMID: 23615901
  5. Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in vesicular trafficking, these studies may identify a new gene involved in the development of bone diseases including osteoporosis. PMID: 22174188
  6. Identification of SNX10 as a new osteopetrosis associated gene in consanguineous families of Palestinian origin. PMID: 22499339
  7. SNX10 regulates the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. PMID: 21844891
  8. SNX10 activity may be involved in the regulation of endosome homeostasis PMID: 17012226

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Involvement in disease
Osteopetrosis, autosomal recessive 8 (OPTB8)
Subcellular Location
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
Protein Families
Sorting nexin family
Database Links

HGNC: 14974

OMIM: 614780

KEGG: hsa:29887

STRING: 9606.ENSP00000343709

UniGene: Hs.741316

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