SOCS2 Antibody

Code CSB-PA022389EA01HU
Size US$166
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  • Immunofluorescent analysis of HepG2 cells using CSB-PA022389EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SOCS2 Polyclonal antibody
Uniprot No.
Target Names
SOCS2
Alternative Names
CIS 2 antibody; CIS-2 antibody; CIS2 antibody; Cish 2 antibody; Cish2 antibody; Cytokine inducible SH2 protein 2 antibody; Cytokine-inducible SH2 protein 2 antibody; SOCS 2 antibody; SOCS-2 antibody; Socs2 antibody; SOCS2_HUMAN antibody; SSI 2 antibody; SSI-2 antibody; SSI2 antibody; STAT induced STAT inhibitor 2 antibody; STAT-induced STAT inhibitor 2 antibody; STATI 2 antibody; STATI2 antibody; Suppressor of cytokine signaling 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Suppressor of cytokine signaling 2 protein (1-198AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SOCS2 Antibody (Product code: CSB-PA022389EA01HU) is Non-conjugated. For SOCS2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA022389EB01HU SOCS2 Antibody, HRP conjugated ELISA
FITC CSB-PA022389EC01HU SOCS2 Antibody, FITC conjugated
Biotin CSB-PA022389ED01HU SOCS2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Gene References into Functions
  1. SOCS2 impairs IFN/JAK/STAT signaling through reducing the stability of tyrosine kinase 2 (TYK2), downregulating the expression of type I and III IFN receptors, attenuating the phosphorylation and nucleus translocation of STAT1. PMID: 28496097
  2. High SOCS2 expression is associated with higher grade breast cancer. PMID: 30453988
  3. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
  4. Overexpression of miR-196b suppresses SOCS2 in human laryngeal squamous cell carcinoma resulting in tumor progression and poor prognosis. PMID: 29753737
  5. Methyltransferase-like 3 represses SOCS2 expression in hepatocellular carcinoma through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis PMID: 29171881
  6. Study in lung cancer BEAS-2B cells shows that SOCS2 binding to the growth hormone receptor (GHR) is impaired by a GHR threonine substitution at Pro 495. This results in decreased internalisation and degradation of the receptor. PMID: 28967904
  7. Despite of the key role of SOCS2 in the regulation of GH receptor signaling, study did not find any significant association between SOCS2 polymorphisms and acromegaly. PMID: 27900634
  8. The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor kappaB activation and proinflammatory cytokine production (properties of tolerogenic DCs). PMID: 27330188
  9. Long-term palmitate treatment up-regulates SOCS2 and reduces PI3K activity, thereby impairing glucose stimulated insulin secretion. PMID: 27566229
  10. Targeting of SOCS2 by miR-194 resulted in derepression of the oncogenic kinases FLT3 and JAK2, leading to enhanced ERK and STAT3 signaling. PMID: 28011622
  11. Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma. PMID: 28666115
  12. this study shows that IL-7 induces the expression of SOCS2 through the JAK/STAT-5 pathway and that SOCS2 interacts with CD127 in early endosomes and direct the receptor complex to the proteasome for degradation PMID: 27423467
  13. Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR-H9-5p could be used as a potential target in lung cancer therapy PMID: 28468588
  14. Overexpression of SOCS-2 is associated with hepatocellular carcinoma. PMID: 27465557
  15. focus on SOCS2 and review its biological function as well as its implication in pathological processes PMID: 26709655
  16. SOCS2 may improve outcome of TBI in mice by regulating aspects of the neuroinflammatory response PMID: 27071013
  17. This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains. PMID: 25286386
  18. crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments. PMID: 26121586
  19. miR-101 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing SOCS2 expression. PMID: 25561270
  20. our study indicates that high SOCS2 expression is associated with poor survival in pediatric AML. PMID: 24559289
  21. This study shows that over-expression of SOCS2 reduces the psychostimulant effects of amphetamine, enhances PPI, and alters mesolimbic dopaminergic activity. PMID: 25283341
  22. The SOCS2 polymorphism (rs3782415) has an influence on the adult height of children with Turner syndrome and growth hormone deficiency after long-term therapy. PMID: 24905066
  23. SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer. PMID: 24280133
  24. Stage-independent downregulation of SOCS2 and SOCS6 correlate with disease-free survival in colorectal cancer. PMID: 25025962
  25. SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer. PMID: 24031028
  26. SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. PMID: 23548639
  27. Estradiol can amplify GH intracellular signaling in human osteoblasts with an essential role played by the reduction of the SOCS2 mediated feedback loop. PMID: 23567159
  28. SOCS2 and SOCS6 expression are remarkably reduced in hepatocellular carcinoma and correlate with aggressive tumor progression and poor prognosis PMID: 23475171
  29. Simultaneous stimulation of monocyte-derived DCs resulted in highly increased production of IL-1beta, IL-23 and SOCS2. PMID: 22795647
  30. Data demonstrated that suppressor of cytokine signaling 2 (SOCS2) protein level was distinctively increased by saponin, which in turn resulted in inhibition of HCV replication. PMID: 22745742
  31. High SOCS2 is associated with idiopathic short stature. PMID: 22768656
  32. LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop. PMID: 22291912
  33. We propose a model in which SOCS2 acts as a negative regulator of TLR-induced dendritic cell activation PMID: 21844389
  34. Data show that knockdown of SOCS2 resulted in the accumulation of p-Pyk2(Tyr402) and blocked NK cell effector functions. PMID: 20543098
  35. Probiotic administration increased expression of SOCS-2 and SOCS-3 in Helicobacter pylori infection to limit inflammatory signaling. PMID: 20136974
  36. SOCS2 is required for appropriate TLR4 signaling in maturating human DCs via both the MyD88-dependent and -independent signaling pathway PMID: 19779605
  37. SOCS-2 is overexpressed in advanced stages of chronic myeloid leukemia. It may be a component of a negative feedback mechanism that is functioning inadequately, induced by Bcr-Abl but unable to reverse its growth-promoting effects. PMID: 11861294
  38. SOCS2 mediates the suppression of JAK2 phosphorylation by estrogen, which inhibits growth hormone signaling PMID: 12552091
  39. Association of single-nucleotide polymorphisms in the SOCS2 gene with type 2 diabetes in the Japanese was studied. PMID: 16406727
  40. Results describe the 1.9-A crystal structure of the ternary complex of SOCS2 with elongin C and elongin B. PMID: 16675548
  41. SOCS2 only interacts with the Y1077 motif, but with higher binding affinity and can interfere with CIS and STAT5a prey recruitment at this site. PMID: 16684815
  42. Using RT-PCR, we demonstrated for the first time that neutrophils express mRNA for SOCS-2. PMID: 17264307
  43. A defect in expression of SOCS-2 and SOCS-3 genes may be crucial for the IGF-I hypersensitivity and progressive increase in erythroid cell population size characteristic of Polycythemia vera. PMID: 17325857
  44. Favorable prognostic value of high SOCS2 expression in primary mammary carcinomas. PMID: 17651480
  45. analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor PMID: 17666591
  46. SOCS2 epigenetic downregulation might be an important second step in the genesis of cytokine-independent myeloproliferative disorder clones PMID: 18769447
  47. Acromegalic patients with active disease and hyperplastic polyps had higher levels of SOCS2 transcripts. PMID: 18844680
  48. role of SOCS-2 in mediating HIV-1-induced immune evasion and dysregulation of IFNgamma signaling in primary human monocytes PMID: 19279332
  49. SOCS2 expression is regulated by STAT5. PMID: 17008382

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Tissue Specificity
High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.
Database Links

HGNC: 19382

OMIM: 605117

KEGG: hsa:8835

STRING: 9606.ENSP00000339428

UniGene: Hs.485572

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