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SOCS4 Antibody

Datasheet
Code CSB-PA022393ESR1HU
Size US$299
Image

  • Western blot
    All lanes: SOCS4 antibody at 4.39 μg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Jurkat whole cell lysate
    Lane 3: A549 whole cell lysate
    Lane 4: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 60 kDa
    Observed band size: 60 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022393ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA022393ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) SOCS4 Polyclonal antibody
Uniprot No. Q8WXH5
Target Names SOCS4
Alternative Names CIS4 antibody; Cish4 antibody; Cytokine inducible SH2 protein 4 antibody; DKFZp686J1568 antibody; HSPC060 antibody; SH2 domain containing SOCS box protein antibody; SOCS-4 antibody; SOCS-7 antibody; SOCS4 antibody; SOCS4_HUMAN antibody; SOCS6 antibody; SOCS7 antibody; SSI4 antibody; STAI4 antibody; STAT induced STAT inhibitor 4 antibody; STAT4 antibody; STATI4 antibody; Suppressor of cytokine signaling 4 antibody; Suppressor of cytokine signaling 7 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Suppressor of cytokine signaling 4 protein (1-270AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Gene References into Functions
  1. Significantly higher levels of suppressor of cytokine signalling proteins SOCS3 and SOCS4 in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. PMID: 27635428
  2. miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. PMID: 26437444
  3. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains. PMID: 25286386
  4. SOCS4 is a known inhibitor of epidermal growth factor (EGF) receptor signalling, and functional studies demonstrated specific upregulation of EGF-dependent immune stimulation in affected family members. PMID: 25639832
  5. Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
  6. The expression of SOCS4 seems to be controlled epigenetically and is often weakly expressed in gastric cancer tissue and cell lines. SOCS4 methylation status could be a predictor of gastric cancer prognosis. PMID: 22127425
  7. Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer. PMID: 20433750
  8. These data suggest that miRNAs play an important role in the regulation of cytokine-inducible Src homology and SOCS expression in epithelial cells in response to C. parvum infection. PMID: 20486857
  9. the expression of SOCS5 and its closest homolog SOCS4 is elevated in cells following treatment with EGF, similar to several negative feedback regulators of EGFR whose expression is up-regulated upon receptor activation. PMID: 15590694
  10. The structure of the SOCS4-ElonginC-ElonginB complex reveals a distinct SOCS structural class. PMID: 17997974

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Database Links

HGNC: 19392

OMIM: 616337

KEGG: hsa:122809

STRING: 9606.ENSP00000341327

UniGene: Hs.744302
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