SOCS4 Antibody

1. Significantly higher levels of suppressor of cytokine signalling proteins SOCS3 and SOCS4 in non-healing chronic wounds compared to the healing/healed chronic wounds were observed at the transcript level. PMID: 27635428
2. miR-25 promotes the migration and invasion of thyroid cancer cells by directly binding to the 3'-UTR of SOCS4 that leads to the inhibition of SOCS4. PMID: 26437444
3. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains. PMID: 25286386
4. SOCS4 is a known inhibitor of epidermal growth factor (EGF) receptor signalling, and functional studies demonstrated specific upregulation of EGF-dependent immune stimulation in affected family members. PMID: 25639832
5. Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
6. The expression of SOCS4 seems to be controlled epigenetically and is often weakly expressed in gastric cancer tissue and cell lines. SOCS4 methylation status could be a predictor of gastric cancer prognosis. PMID: 22127425
7. Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer. PMID: 20433750
8. These data suggest that miRNAs play an important role in the regulation of cytokine-inducible Src homology and SOCS expression in epithelial cells in response to C. parvum infection. PMID: 20486857
9. the expression of SOCS5 and its closest homolog SOCS4 is elevated in cells following treatment with EGF, similar to several negative feedback regulators of EGFR whose expression is up-regulated upon receptor activation. PMID: 15590694
10. The structure of the SOCS4-ElonginC-ElonginB complex reveals a distinct SOCS structural class. PMID: 17997974

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HGNC: 19392

OMIM: 616337

KEGG: hsa:122809

STRING: 9606.ENSP00000341327

UniGene: Hs.744302