SRRM4 Antibody

Datasheet

Code	CSB-PA012292LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat kidney tissue, Mouse lung tissue All lanes: SRRM4 antibody at 4.2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 69 kDa Observed band size: 69 kDa IHC image of CSB-PA012292LA01HU diluted at 1:500 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SRRM4 Polyclonal antibody

Uniprot No.

A7MD48

Target Names

SRRM4

Alternative Names

SRRM4 antibody; KIAA1853 antibody; Serine/arginine repetitive matrix protein 4 antibody; Medulloblastoma antigen MU-MB-2.76 antibody; Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody; Neural-specific SR-related protein of 100 kDa antibody; nSR100 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SRRM4 Antibody (Product code: CSB-PA012292LA01HU) is Non-conjugated. For SRRM4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012292LB01HU	SRRM4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012292LC01HU	SRRM4 Antibody, FITC conjugated
Biotin	CSB-PA012292LD01HU	SRRM4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.

Gene References into Functions

data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. PMID: 27180064
Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. PMID: 27984743
The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. PMID: 25525873
findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058

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Subcellular Location

Nucleus.

Protein Families

NSR100 family

Tissue Specificity

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.

Database Links

HGNC: 29389

OMIM: 613103

KEGG: hsa:84530

STRING: 9606.ENSP00000267260

UniGene: Hs.744964

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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